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Literature DB >> 9177276

Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP.

Z Zhang¹, Y Zhao, Y Batres, M F Lin, S Y Ying.

Abstract

Activin A, a homodimer of the betaA subunit of inhibin, is a member of the TGF-beta family. It is a multifunctional molecule regulating the growth, differentiation, and survival of a variety of cells. Treatment with activin A to an androgen-sensitive human prostatic cancer cell line LNCaP resulted in growth and morphological change and those were accompanied by up-regulation of prostatic differentiation markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). In addition, the expression of androgen receptor was also enhanced by activin treatment. These results suggest that activin has significant influence on LNCaP cells.

Entities: Disease Gene Species

Mesh：

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Year: 1997 PMID： 9177276 DOI： 10.1006/bbrc.1997.6649

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

10 in total

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Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP.

1. Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin.

2. Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma.

Review 3. New insights into ovarian function.

4. Overexpression of activin A in stage IV colorectal cancer.

5. Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study).

6. Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays.

7. Activin receptor signaling regulates prostatic epithelial cell adhesion and viability.

8. Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer.

9. Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues.

10. Change in the Gastro-Intestinal Tract by Overexpressed Activin Beta A.