Literature DB >> 9177122

On extending the transmission/disequilibrium test (TDT).

S R Wilson1.   

Abstract

The transmission/disequilibrium test (TDT), for evaluation of the null hypothesis of neither linkage nor association between a marker locus and disease, is extended to the more general situation of transmission of two multi-allele marker loci from parents to affected offspring. Transmission probabilities are derived for a generalized single locus disease model, where the disease locus is taken to lie between the two marker loci. There could be unlinked modifier loci for the disease. Examples of the extended TDT are given and it is shown how the contribution from each locus can be evaluated, both separately and jointly.

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Year:  1997        PMID： 9177122     DOI： 10.1046/j.1469-1809.1997.6120151.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  10 in total

1.  Transmission/disequilibrium test meets measured haplotype analysis: family-based association analysis guided by evolution of haplotypes.

Authors:  H Seltman; K Roeder; B Devlin
Journal:  Am J Hum Genet       Date:  2001-04-10       Impact factor: 11.025

2.  Transmission/disequilibrium tests using multiple tightly linked markers.

Authors:  H Zhao; S Zhang; K R Merikangas; M Trixler; D B Wildenauer; F Sun; K K Kidd
Journal:  Am J Hum Genet       Date:  2000-08-31       Impact factor: 11.025

3.  Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers.

Authors:  Rong Cheng; Jennie Z Ma; Fred A Wright; Shili Lin; Xin Gao; Daolong Wang; Robert C Elston; Ming D Li
Journal:  Genetics       Date:  2003-07       Impact factor: 4.562

4.  An entropy-based genome-wide transmission/disequilibrium test.

Authors:  Jinying Zhao; Eric Boerwinkle; Momiao Xiong
Journal:  Hum Genet       Date:  2007-02-13       Impact factor: 4.132

Review 5.  Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles.

Authors:  Hemant K Tiwari; Jill Barnholtz-Sloan; Nathan Wineinger; Miguel A Padilla; Laura K Vaughan; David B Allison
Journal:  Hum Hered       Date:  2008-03-31       Impact factor: 0.444

6.  Transmission/disequilibrium tests for multiallelic loci.

Authors:  P Sham
Journal:  Am J Hum Genet       Date:  1997-09       Impact factor: 11.025

7.  Haplotype-based score test for linkage in nuclear families.

Authors:  Chung Mo Nam; Dae Ryong Kang; Jinheum Kim
Journal:  BMC Bioinformatics       Date:  2007-08-01       Impact factor: 3.169

8.  Analysis of Case-Parent Trios Using a Loglinear Model with Adjustment for Transmission Ratio Distortion.

Authors:  Lam O Huang; Claire Infante-Rivard; Aurélie Labbe
Journal:  Front Genet       Date:  2016-08-31       Impact factor: 4.599

9.  Innovative approach to identify multigenomic and environmental interactions associated with birth defects in family-based hybrid designs.

Authors:  Xiang-Yang Lou; Ting-Ting Hou; Shou-Ye Liu; Hai-Ming Xu; Feng Lin; Xinyu Tang; Stewart L MacLeod; Mario A Cleves; Charlotte A Hobbs
Journal:  Genet Epidemiol       Date:  2020-09-30       Impact factor: 2.344

10.  Application of association mapping to understanding the genetic diversity of plant germplasm resources.

Authors:  Ibrokhim Y Abdurakhmonov; Abdusattor Abdukarimov
Journal:  Int J Plant Genomics       Date:  2008
  10 in total

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