Literature DB >> 9175619

NMDA receptor-dependent and -independent long-term depression in the CA1 region of the adult rat hippocampus in vitro.

N Kemp1, Z I Bashir.   

Abstract

We have investigated different stimulus parameters in an attempt to induce long-term depression (LTD) in the CA1 region of adult rat hippocampus in vitro. Whereas 900 stimuli delivered at 1 Hz failed to induce LTD, 900 stimuli when delivered as 450 pairs (50 msec inter-stimulus interval) at 1 Hz induced significant and stable N-methyl-D-aspartate (NMDA) receptor-dependent LTD. However, 900 paired stimuli at 1 Hz induced LTD which was only partly blocked by the NMDA receptor antagonist, D-2-amino-5-phosphonopentanoate (AP5).

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Year:  1997        PMID： 9175619     DOI： 10.1016/s0028-3908(96)90015-5

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  17 in total

1.  G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region.

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Authors:  Jossina Gonzalez; Isaiah S Morales; Desiree M Villarreal; Brian E Derrick
Journal:  J Neurophysiol       Date:  2013-12-11       Impact factor: 2.714

5.  Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.

Authors:  Ashok Kumar; Thomas C Foster
Journal:  Hippocampus       Date:  2014-01-14       Impact factor: 3.899

6.  Slice orientation and muscarinic acetylcholine receptor activation determine the involvement of N-methyl D-aspartate receptor subunit GluN2B in hippocampal area CA1 long-term depression.

Authors:  Thomas E Bartlett; Jie Lu; Yu Tian Wang
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7.  Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity.

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8.  Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning.

Authors:  Jian Xu; Yongling Zhu; Stephen Kraniotis; Qionger He; John J Marshall; Toshihiro Nomura; Shaun R Stauffer; Craig W Lindsley; P Jeffrey Conn; Anis Contractor
Journal:  Learn Mem       Date:  2013-07-18       Impact factor: 2.460

9.  mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.

Authors:  Jennifer E Ayala; Yelin Chen; Jessica L Banko; Douglas J Sheffler; Richard Williams; Alexandra N Telk; Noreen L Watson; Zixiu Xiang; Yongqin Zhang; Paulianda J Jones; Craig W Lindsley; M Foster Olive; P Jeffrey Conn
Journal:  Neuropsychopharmacology       Date:  2009-03-18       Impact factor: 7.853

10.  Synaptic depression in the CA1 region of freely behaving mice is highly dependent on afferent stimulation parameters.

Authors:  Jinzhong J Goh; Denise Manahan-Vaughan
Journal:  Front Integr Neurosci       Date:  2013-01-25
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