Literature DB >> 9174994

Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1.

P S Herson1, M L Ashford.   

Abstract

1. Alloxan and its auto-oxidation product hydrogen peroxide (H2O2) irreversibly depolarize insulinoma cells by opening a non-selective cation channel. The channel opened is characterized by a linear current-voltage relation with a conductance of approximately 70 pS and very slow kinetics (of the order of seconds). 2. Cells are protected against the alloxan-induced channel opening and consequent cell depolarization by the presence of H2O2 and hydroxyl radical scavengers. 3. The free radical-activated non-selective cation channel is not operative in isolated patches but can be activated by the application of beta-NAD+ to the cytoplasmic aspect of the membrane.

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Year:  1997        PMID： 9174994      PMCID： PMC1159504          DOI： 10.1111/j.1469-7793.1997.059bo.x

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  17 in total

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Authors:  P M Dean; E K Matthews
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3.  Inhibition of alloxan action in isolated pancreatic islets by superoxide dismutase, catalase, and a metal chelator.

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5.  Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.

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6.  Mechanisms of streptozotocin- and alloxan-induced damage in rat B cells.

Authors:  G L Wilson; N J Patton; J M McCord; D W Mullins; B T Mossman
Journal:  Diabetologia       Date:  1984-12       Impact factor: 10.122

7.  Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro.

Authors:  K Grankvist; S Marklund; J Sehlin; I B Täljedal
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Authors:  I N Nomikos; S J Prowse; P Carotenuto; K J Lafferty
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8.  Reduced glutathione inhibits beta-NAD+-activated non-selective cation currents in the CRI-G1 rat insulin-secreting cell line.

Authors:  P S Herson; M L Ashford
Journal:  J Physiol       Date:  1999-01-01       Impact factor: 5.182

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