M L Løchen1, E Lund. 1. Institute of Community Medicine, University of Tromsø, Norway.
Abstract
BACKGROUND: To investigate the mortality from cancer of the corpus uteri in relation to parity and age at first and last birth. METHODS: A cohort of 431,604 married women aged 45-74 years at the Norwegian Census in 1970 was followed over 15 years. A total of 752 deaths from cancer of the corpus uteri were diagnosed during follow-up. RESULTS: All age groups showed significant trends of decreasing mortality rates with increasing number of children. The age-adjusted reduction in mortality was 9.2% (95% CI 5.2-13.0) for each child. Women with 8-11 children had a relative risk of 0.35 (95% CI 0.14-0.85) compared to nulliparous women. For first birth at age > = 35 years versus < = 19 years, the relative risk was 0.53 (95% CI 0.34-0.83). No significant effect of age at last birth was found. CONCLUSIONS: This study supports the notion that high parity and postponing the first delivery may reduce the risk of uterine cancer death.
BACKGROUND: To investigate the mortality from cancer of the corpus uteri in relation to parity and age at first and last birth. METHODS: A cohort of 431,604 married women aged 45-74 years at the Norwegian Census in 1970 was followed over 15 years. A total of 752 deaths from cancer of the corpus uteri were diagnosed during follow-up. RESULTS: All age groups showed significant trends of decreasing mortality rates with increasing number of children. The age-adjusted reduction in mortality was 9.2% (95% CI 5.2-13.0) for each child. Women with 8-11 children had a relative risk of 0.35 (95% CI 0.14-0.85) compared to nulliparous women. For first birth at age > = 35 years versus < = 19 years, the relative risk was 0.53 (95% CI 0.34-0.83). No significant effect of age at last birth was found. CONCLUSIONS: This study supports the notion that high parity and postponing the first delivery may reduce the risk of uterine cancer death.
Authors: Yakir Segev; Barry Rosen; Jan Lubinski; Jacek Gronwald; Henry T Lynch; Pal Moller; Charmaine Kim-Sing; Parviz Ghadirian; Beth Karlan; Charis Eng; Dawna Gilchrist; Susan L Neuhausen; Andrea Eisen; Eitan Friedman; David Euhus; Sun Ping; Steven A Narod Journal: Fam Cancer Date: 2015-09 Impact factor: 2.375
Authors: Ashley S Felix; D Scott McMeekin; David Mutch; Joan L Walker; William T Creasman; David E Cohn; Shamshad Ali; Richard G Moore; Levi S Downs; Olga B Ioffe; Kay J Park; Mark E Sherman; Louise A Brinton Journal: Gynecol Oncol Date: 2015-09-01 Impact factor: 5.482