OBJECTIVE: To determine the effect of bottle feeding, as compared to two methods of gavage feeding, on apnoea, bradycardia and oxygen desaturation frequency. PATIENTS: Thirty preterm infants breathing room air; gestational age 28.6 +/- 2.1 weeks at birth and 34 +/- 1.4 weeks at study (mean +/- SD). METHODS: Nine-hour recordings of pulse oximeter saturation (SpO2), pulse waveforms, electrocardiogram, breathing movements and nasal airflow. Administration of 21 +/- 1.5 ml/kg of milk/feed in 3-h intervals using three different feeding techniques in random order: bottle feeding, bolus gavage feeding, and slow gavage feeding (1 h). Analysis of recordings for apnoeas (> or =4s, bradycardias (heart rate < 2/3 of baseline), and episodic desaturation (SpO2 < or = 80%). RESULTS: There were three times more desaturations with bottle feeding than with bolus gavage feeding (p < 0.001), but no further reduction with slow gavage feeding. With all three feeding techniques, there were significantly more desaturations in the hour when the feeds were given than during the following 2 h. The deleterious effects of bottle feeding were most evident during the hour of feeding, but desaturation frequency remained significantly higher than with gavage feeding during the following 2 h. There was no significant effect of feeding technique on the frequency of apnoea or bradycardia. CONCLUSIONS:Preterm infants who are normally oxygenated in room air may have significant desaturation during bottle feeding. Such desaturation can be effectively reduced by gavage feeding. Slow gavage feeding offers no advantage over bolus gavage feeding with respect to the avoidance of hypoxaemia.
RCT Entities:
OBJECTIVE: To determine the effect of bottle feeding, as compared to two methods of gavage feeding, on apnoea, bradycardia and oxygen desaturation frequency. PATIENTS: Thirty preterm infants breathing room air; gestational age 28.6 +/- 2.1 weeks at birth and 34 +/- 1.4 weeks at study (mean +/- SD). METHODS: Nine-hour recordings of pulse oximeter saturation (SpO2), pulse waveforms, electrocardiogram, breathing movements and nasal airflow. Administration of 21 +/- 1.5 ml/kg of milk/feed in 3-h intervals using three different feeding techniques in random order: bottle feeding, bolus gavage feeding, and slow gavage feeding (1 h). Analysis of recordings for apnoeas (> or =4s, bradycardias (heart rate < 2/3 of baseline), and episodic desaturation (SpO2 < or = 80%). RESULTS: There were three times more desaturations with bottle feeding than with bolus gavage feeding (p < 0.001), but no further reduction with slow gavage feeding. With all three feeding techniques, there were significantly more desaturations in the hour when the feeds were given than during the following 2 h. The deleterious effects of bottle feeding were most evident during the hour of feeding, but desaturation frequency remained significantly higher than with gavage feeding during the following 2 h. There was no significant effect of feeding technique on the frequency of apnoea or bradycardia. CONCLUSIONS: Preterm infants who are normally oxygenated in room air may have significant desaturation during bottle feeding. Such desaturation can be effectively reduced by gavage feeding. Slow gavage feeding offers no advantage over bolus gavage feeding with respect to the avoidance of hypoxaemia.
Authors: Sourabh Dutta; Balpreet Singh; Lorraine Chessell; Jennifer Wilson; Marianne Janes; Kimberley McDonald; Shaneela Shahid; Victoria A Gardner; Aune Hjartarson; Margaret Purcha; Jennifer Watson; Chris de Boer; Barbara Gaal; Christoph Fusch Journal: Nutrients Date: 2015-01-08 Impact factor: 5.717