Literature DB >> 9174206

Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study.

L Aguilar1, J Rosendo, I P Balcabao, M Martín, M J Giménez, J Frías, J Prieto.   

Abstract

Serum bactericidal activity against a penicillin-susceptible strain and a penicillin-resistant strain of Streptococcus pneumoniae (amoxicillin and cefotaxime MICs, 0.001 and 1 microg/ml, respectively, and MBCs, 0.01 and 2 microg/ml, respectively) was measured in 12 healthy volunteers who each received an oral 875-mg dose of amoxicillin and an intramuscular 1-g dose of cefotaxime in a crossover fashion. The areas under the bactericidal activity-time curves for the two strains were found to be similar for both antibiotics despite the significantly higher (P < 0.002) AUC/MIC and peak level/MIC values for cefotaxime.

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Year:  1997        PMID： 9174206      PMCID： PMC163922          DOI： 10.1128/AAC.41.6.1389

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Activities against Streptococcus pneumoniae of amoxicillin and cefotaxime at physiological concentrations: in vitro pharmacodynamic simulation.

Authors:  I P Balcabao; L Aguilar; M Martín; Y García; R Dal-Ré; J Prieto
Journal:  Antimicrob Agents Chemother       Date:  1996-12       Impact factor: 5.191

2.  Antibacterial activity in serum and urine as a therapeutic guide in bacterial infections.

Authors:  J Klastersky; D Daneau; G Swings; D Weerts
Journal:  J Infect Dis       Date:  1974-02       Impact factor: 5.226

Review 3.  Drug therapy. Serum bactericidal activity as a monitor of antibiotic therapy.

Authors:  J S Wolfson; M N Swartz
Journal:  N Engl J Med       Date:  1985-04-11       Impact factor: 91.245

4.  The bactericidal activity in serum and its prognostic clinical value.

Authors:  J Klastersky
Journal:  Infection       Date:  1983       Impact factor: 3.553

Review 5.  Antimicrobial resistance in Streptococcus pneumoniae: an overview.

Authors:  P C Appelbaum
Journal:  Clin Infect Dis       Date:  1992-07       Impact factor: 9.079

Review 6.  Management of infections caused by antibiotic-resistant Streptococcus pneumoniae.

Authors:  I R Friedland; G H McCracken
Journal:  N Engl J Med       Date:  1994-08-11       Impact factor: 91.245

7.  Bactericidal activity of ciprofloxacin, norfloxacin and ofloxacin in serum and urine after oral administration to healthy volunteers.

Authors:  H J Zeiler; D Beermann; W Wingender; D Förster; P Schacht
Journal:  Infection       Date:  1988       Impact factor: 3.553

8.  Assessment of serum bactericidal activity after administration of cefoperazone, cefotaxime, ceftizoxime, and moxalactam to healthy subjects.

Authors:  S L Barriere; D C Ozasa; J Mordenti
Journal:  Antimicrob Agents Chemother       Date:  1985-07       Impact factor: 5.191

9.  Correlation of serum bactericidal activity with antimicrobial agent level and minimal bactericidal concentration.

Authors:  C W Stratton; M P Weinstein; L B Reller
Journal:  J Infect Dis       Date:  1982-02       Impact factor: 5.226

10.  Comparative serum bactericidal activity of ceftizoxime/metronidazole, ceftizoxime, clindamycin, and imipenem against obligate anaerobic bacteria.

Authors:  S F Kowalsky; R M Echols; E M McCormick
Journal:  J Antimicrob Chemother       Date:  1990-05       Impact factor: 5.790
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  1 in total

1.  Effect of polymorphonuclear neutrophils on serum bactericidal activity against Streptococcus pneumoniae after amoxicillin administration.

Authors:  M L Gómez-Lus; M J Giménez; J Prieto; M Martín; J Frías; L Aguilar
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1998-01       Impact factor: 3.267
  1 in total

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