BACKGROUND: [111In-DTPA-D-Phe1]-pentetreotide scintigraphy is able to detect neuroendocrine tumors not shown by radiological methods. PATIENTS AND METHODS: In 270 patients with neuroendocrine gastroenteropancreatic tumors (GEP tumors) 400 somatostatin receptor scintigraphies were performed. 70 patients (38 female, 32 male, aged 28 to 74 [56 +/- 12.6] years) underwent surgery and follow-up over 2 years. The aim of the present study was the comparison of preoperative somatostatin receptor scintigraphy with radiological methods (sonography, CT) and intraoperative localization of GEP tumors with a hand-held gamma-probe. RESULTS: Somatostatin receptor scintigraphy was successful in localizing primary tumors in all patients. Liver- and lymph node metastases could be visualized with a sensitivity of 94 and 95 percent. In 7 patients 35 lesions could be identified by intraoperative tumor localization using a hand held gamma probe. Radiological methods identified only 11, surgical palpation 15 and preoperative somatostatin receptor scintigraphy 27 lesions. CONCLUSION: Somatostatin receptor scintigraphy improves detection of small and occult GEP tumors. Intraoperative probe counting with a hand-held gamma probe can identify tumors even when they are small and impalpable, but receptor positive.
BACKGROUND:[111In-DTPA-D-Phe1]-pentetreotide scintigraphy is able to detect neuroendocrine tumors not shown by radiological methods. PATIENTS AND METHODS: In 270 patients with neuroendocrine gastroenteropancreatic tumors (GEP tumors) 400 somatostatin receptor scintigraphies were performed. 70 patients (38 female, 32 male, aged 28 to 74 [56 +/- 12.6] years) underwent surgery and follow-up over 2 years. The aim of the present study was the comparison of preoperative somatostatin receptor scintigraphy with radiological methods (sonography, CT) and intraoperative localization of GEP tumors with a hand-held gamma-probe. RESULTS: Somatostatin receptor scintigraphy was successful in localizing primary tumors in all patients. Liver- and lymph node metastases could be visualized with a sensitivity of 94 and 95 percent. In 7 patients 35 lesions could be identified by intraoperative tumor localization using a hand held gamma probe. Radiological methods identified only 11, surgical palpation 15 and preoperative somatostatin receptor scintigraphy 27 lesions. CONCLUSION: Somatostatin receptor scintigraphy improves detection of small and occult GEP tumors. Intraoperative probe counting with a hand-held gamma probe can identify tumors even when they are small and impalpable, but receptor positive.
Authors: K Joseph; J Stapp; J Reinecke; H Höffken; R Benning; C Neuhaus; M E Trautmann; W B Schwerk; R Arnold Journal: Dtsch Med Wochenschr Date: 1992-06-26 Impact factor: 0.628
Authors: S W Lamberts; L J Hofland; P M van Koetsveld; J C Reubi; H A Bruining; W H Bakker; E P Krenning Journal: J Clin Endocrinol Metab Date: 1990-09 Impact factor: 5.958
Authors: E P Krenning; W H Bakker; W A Breeman; J W Koper; P P Kooij; L Ausema; J S Lameris; J C Reubi; S W Lamberts Journal: Lancet Date: 1989-02-04 Impact factor: 79.321
Authors: E P Krenning; D J Kwekkeboom; H Y Oei; J C Reubi; P M van Hagen; P P Kooij; A E Reijs; S W Lamberts Journal: Schweiz Med Wochenschr Date: 1992-04-25
Authors: K Joseph; J Stapp; J Reinecke; H J Skamel; H Höffken; R Benning; C Neuhaus; H Lenze; M E Trautmann; R Arnold Journal: Nuklearmedizin Date: 1993-12 Impact factor: 1.379