Literature DB >> 9171916

The physiological significance of mitochondrial proton leak in animal cells and tissues.

D F Rolfe1, M D Brand.   

Abstract

Mitochondrial proton leak is an important component of cellular metabolism in animals and may account for as much as one quarter to one third of the Standard Metabolic Rate of the rat. The activity of the proton leak pathway is different in a wide range of animal species and in different thyroid states. Such differences imply some function for proton leak and candidates for this function include thermogenesis, protection against reactive oxygen species, endowment of metabolic sensitivity and maintenance of carbon fluxes.

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Year:  1997        PMID： 9171916     DOI： 10.1023/a:1027327015957

Source DB:  PubMed          Journal:  Biosci Rep        ISSN： 0144-8463            Impact factor:   3.840


  46 in total

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