Literature DB >> 9171865

17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action.

L Quadri1, G Bianchi, A Cerri, G Fedrizzi, P Ferrari, M Gobbini, P Melloni, S Sputore, M Torri.   

Abstract

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Year:  1997        PMID： 9171865     DOI： 10.1021/jm970162e

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  14 in total

1.  Ouabain binding to Na+,K+-ATPase relaxes cell attachment and sends a specific signal (NACos) to the nucleus.

Authors:  R G Contreras; C Flores-Maldonado; A Lázaro; L Shoshani; D Flores-Benitez; I Larré; M Cereijido
Journal:  J Membr Biol       Date:  2004-04-01       Impact factor: 1.843

Review 2.  Pivotal role of α2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease.

Authors:  Mordecai P Blaustein; Ling Chen; John M Hamlyn; Frans H H Leenen; Jerry B Lingrel; W Gil Wier; Jin Zhang
Journal:  J Physiol       Date:  2016-07-31       Impact factor: 5.182

Review 3.  Endogenous cardiotonic steroids in kidney failure: a review and an hypothesis.

Authors:  John M Hamlyn; Paolo Manunta
Journal:  Adv Chronic Kidney Dis       Date:  2015-05       Impact factor: 3.620

Review 4.  How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension.

Authors:  Mordecai P Blaustein; Frans H H Leenen; Ling Chen; Vera A Golovina; John M Hamlyn; Thomas L Pallone; James W Van Huysse; Jin Zhang; W Gil Wier
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-11-04       Impact factor: 4.733

Review 5.  Signaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins.

Authors:  Mordecai P Blaustein; John M Hamlyn
Journal:  Biochim Biophys Acta       Date:  2010-03-06

Review 6.  The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na+ pump endocrine system.

Authors:  Mordecai P Blaustein
Journal:  Am J Physiol Cell Physiol       Date:  2017-11-07       Impact factor: 4.249

7.  Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice.

Authors:  Jin Zhang; Moo Yeol Lee; Maurizio Cavalli; Ling Chen; Roberto Berra-Romani; C William Balke; Giuseppe Bianchi; Patrizia Ferrari; John M Hamlyn; Takahiro Iwamoto; Jerry B Lingrel; Donald R Matteson; W Gil Wier; Mordecai P Blaustein
Journal:  J Physiol       Date:  2005-09-15       Impact factor: 5.182

Review 8.  The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension.

Authors:  Mordecai P Blaustein; Jin Zhang; Ling Chen; Hong Song; Hema Raina; Stephen P Kinsey; Michelle Izuka; Takahiro Iwamoto; Michael I Kotlikoff; Jerry B Lingrel; Kenneth D Philipson; W Gil Wier; John M Hamlyn
Journal:  Hypertension       Date:  2008-12-22       Impact factor: 10.190

9.  Ouabain-digoxin antagonism in rat arteries and neurones.

Authors:  Hong Song; Eiji Karashima; John M Hamlyn; Mordecai P Blaustein
Journal:  J Physiol       Date:  2013-12-16       Impact factor: 5.182

10.  Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin.

Authors:  Jan A Staessen; Lutgarde Thijs; Katarzyna Stolarz-Skrzypek; Antonella Bacchieri; John Barton; Ezio Degli Espositi; Peter W de Leeuw; Mirosław Dłużniewski; Nicola Glorioso; Andrzej Januszewicz; Paolo Manunta; Viktor Milyagin; Yuri Nikitin; Miroslav Souček; Chiara Lanzani; Lorena Citterio; Mario Timio; Andrzej Tykarski; Patrizia Ferrari; Giovanni Valentini; Kalina Kawecka-Jaszcz; Giuseppe Bianchi
Journal:  Trials       Date:  2011-01-14       Impact factor: 2.279
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