Effect of undecanoic acid on germination of microconidia of wild and undecanoic acid resistance mutant of Trichophyton rubrum.

Effects of undecanoic acid (UDA) on germination of microconidia and elongation of germ tubes in UDA sensitive (udas) wild type Trichophyton rubrum and UDA resistant (udar) mutant derived from it, were studied. UDA inhibited conidial germination of udas and udar strains at 30 microgram/ml and 120 microgram/ml respectively which were minimum inhibitory concentrations of UDA for these two strains. When spores from both udas and udar were germinated in presence of subinhibitory concentration of UDA, germ tube growth was short. The elongation of germ tubes of spores pregerminated in absence of UDA was also inhibited by dose of UDA not sufficient to inhitib germination.