Literature DB >> 917031

A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): utilization with a variety of mutagenic agents.

J P O'Neill, D B Couch, R Machanoff, J R San Sebastian, P A Brimer, A W Hsie.   

Abstract

The induction of mutation by a variety of mutagens has been measured utilizing the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells (CHO/HGPRT) system). These mutagens include physical agents such as UV light and X-rays, and chemicals such as alkylating agents, ICR-191, and metallic compounds. This system can also be modified for study of the mutagenicity of promutagens such as dimethylnitrosamine (DMN) which require biotransformation for mutagenic action, either through the addition of a rat liver microsomal activation preparation or through a host-mediated activation step using Balb/c athymic mice.

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Year:  1977        PMID： 917031     DOI： 10.1016/0027-5107(77)90048-3

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  8 in total

1.  Detection of deletion mutations in pSV2gpt-transformed cells.

Authors:  K R Tindall; L F Stankowski; R Machanoff; A W Hsie
Journal:  Mol Cell Biol       Date:  1984-07       Impact factor: 4.272

2.  A mutagen-testing assay based on heterogeneity in diameter and integrated optical density of mammalian cell colonies.

Authors:  S H Dairkee; D A Glaser
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

Review 3.  Methods for analysis of the mutagenicity of indirect mutagens/carcinogens in eukaryotic cells.

Authors:  S Madle; G Obe
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

4.  Evidence for reactive oxygen species inducing mutations in mammalian cells.

Authors:  A W Hsie; L Recio; D S Katz; C Q Lee; M Wagner; R L Schenley
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

5.  In vitro assessment of the toxicity of metal compounds : II. Mutagenesis.

Authors:  J D Heck; M Costa
Journal:  Biol Trace Elem Res       Date:  1982-12       Impact factor: 3.738

Review 6.  Effects of metals in in vitro bioassays.

Authors:  M A Sirover
Journal:  Environ Health Perspect       Date:  1981-08       Impact factor: 9.031

7.  Quantitative and molecular analyses of genetic risk: a study with ionizing radiation.

Authors:  A W Hsie; Z Xu; Y Yu; J An; M L Meltz; J L Schwartz; P Hrelia
Journal:  Environ Health Perspect       Date:  1993-10       Impact factor: 9.031

Review 8.  Comparison between carcinogenicity and mutagenicity based on chemicals evaluated in the IARC monographs.

Authors:  H Bartsch; L Tomatis
Journal:  Environ Health Perspect       Date:  1983-01       Impact factor: 9.031
  8 in total

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