| Literature DB >> 9170288 |
H A Oketch-Rabah1, E Lemmich, S F Dossaji, T G Theander, C E Olsen, C Cornett, A Kharazmi, S B Christensen.
Abstract
Two new isomeric 5-methylcoumarins, 2'-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.Entities:
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Year: 1997 PMID： 9170288 DOI： 10.1021/np970030o
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050