Literature DB >> 9169988

Release of amphotericin B from delivery systems and its action against fungal and mammalian cells.

P Legrand1, M Chéron, L Leroy, J Bolard.   

Abstract

Spectroscopic studies of four amphotericin B (AmB) lipid preparations--small negatively charged unilamellar vesicles "AmBisome", positively charged oligolamellar liposomes "Ampholiposomes", AmB Lipid Complex "L-AmpB33"--and AmB association with gamma cyclodextrin demonstrated that the composition of drug delivery system directly influences AmB organization. The aggregation state and release in external medium of AmB was monitored by circular dichroism and UV-visible absorption. AmB short-term activity against Candida albicans (K+ leakage) was found to be correlated with the amount of free AmB released from lipid preparations. These data seem to indicate that lipid composition influences anti-Candida albicans activity, by modulation of AmB binding to lipids.

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Year:  1997        PMID： 9169988     DOI： 10.3109/10611869708995847

Source DB:  PubMed          Journal:  J Drug Target        ISSN： 1026-7158            Impact factor:   5.121


  13 in total

1.  Renal handling of amphotericin B and amphotericin B-deoxycholate and potential renal drug-drug interactions with selected antivirals.

Authors:  František Trejtnar; Jana Mandíková; Jana Kočíncová; Marie Volková
Journal:  Antimicrob Agents Chemother       Date:  2014-06-23       Impact factor: 5.191

2.  Long open amphotericin channels revealed in cholesterol-containing phospholipid membranes are blocked by thiazole derivative.

Authors:  Oleg Ya Shatursky; Olexander V Romanenko; Nina H Himmelreich
Journal:  J Membr Biol       Date:  2014-01-09       Impact factor: 1.843

3.  Reduction of no synthase expression and tumor necrosis factor alpha production in macrophages by amphotericin B lipid carriers.

Authors:  M Larabi; P Legrand; M Appel; S Gil; M Lepoivre; J Devissaguet; F Puisieux; G Barratt
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

4.  The effect of serum albumin on amphotericin B aggregate structure and activity.

Authors:  S C Hartsel; E Bauer; E H Kwong; K M Wasan
Journal:  Pharm Res       Date:  2001-09       Impact factor: 4.200

5.  Activity and kinetics of dissociation and transfer of amphotericin B from a novel delivery form.

Authors:  B Baas; K Kindt; A Scott; J Scott; P Mikulecky; S C Hartsel
Journal:  AAPS PharmSci       Date:  1999

6.  Activity of liposomal amphotericin B with prolonged circulation in blood versus those of AmBisome and fungizone against intracellular Candida albicans in murine peritoneal macrophages.

Authors:  E W van Etten; W van Vianen; J Hak; I A Bakker-Woudenberg
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

7.  Superior efficacy of liposomal amphotericin B with prolonged circulation in blood in the treatment of severe candidiasis in leukopenic mice.

Authors:  E W van Etten; S V Snijders; W van Vianen; I A Bakker-Woudenberg
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

Review 8.  Amphotericin B membrane action: role for two types of ion channels in eliciting cell survival and lethal effects.

Authors:  B Eleazar Cohen
Journal:  J Membr Biol       Date:  2010-11-18       Impact factor: 1.843

9.  Efficacious treatment of experimental leishmaniasis with amphotericin B-arabinogalactan water-soluble derivatives.

Authors:  J Golenser; S Frankenburg; T Ehrenfreund; A J Domb
Journal:  Antimicrob Agents Chemother       Date:  1999-09       Impact factor: 5.191

10.  Comparison of in vitro antifungal activities of free and liposome-encapsulated nystatin with those of four amphotericin B formulations.

Authors:  E M Johnson; J O Ojwang; A Szekely; T L Wallace; D W Warnock
Journal:  Antimicrob Agents Chemother       Date:  1998-06       Impact factor: 5.191
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