PURPOSE: To assess if peritumoral tissue reaction (PTR) can be differentiated from tumor with transrectal ultrasound (TRUS) to avert overstaging. MATERIALS AND METHODS: Preoperative TRUS results in 40 consecutive patients with biopsy-proved rectal cancer were compared with histopathologic reports on the specimens (study 1). To test the hypothesis that areas more anechoic than the tumor were deemed responsible for incorrect staging in study 1, a prospective study was undertaken in another 40 consecutive patients (study 2). The thickest part of PTR was measured, and results were compared with the histopathologic findings. RESULTS: In study 1, 28 (70%) of 40 rectal cancers were staged correctly with TRUS. PTR was responsible for the misinterpretation in six of seven overstaged cases. In study 2, 38 (95%) of 40 cancers were staged correctly, and the presence or absence of PTR was described in 39 cases (98%). A statistically significant positive correlation was noted between histopathologic classification of PTR and its thickness measured with TRUS (P = .0001). CONCLUSION: Because of its more anechoic appearance, PTR may be differentiated from the tumor by means of TRUS. This may lead to a statistically significantly higher accuracy of TRUS in the staging of rectal cancer due to the avoidance of overstaging.
PURPOSE: To assess if peritumoral tissue reaction (PTR) can be differentiated from tumor with transrectal ultrasound (TRUS) to avert overstaging. MATERIALS AND METHODS: Preoperative TRUS results in 40 consecutive patients with biopsy-proved rectal cancer were compared with histopathologic reports on the specimens (study 1). To test the hypothesis that areas more anechoic than the tumor were deemed responsible for incorrect staging in study 1, a prospective study was undertaken in another 40 consecutive patients (study 2). The thickest part of PTR was measured, and results were compared with the histopathologic findings. RESULTS: In study 1, 28 (70%) of 40 rectal cancers were staged correctly with TRUS. PTR was responsible for the misinterpretation in six of seven overstaged cases. In study 2, 38 (95%) of 40 cancers were staged correctly, and the presence or absence of PTR was described in 39 cases (98%). A statistically significant positive correlation was noted between histopathologic classification of PTR and its thickness measured with TRUS (P = .0001). CONCLUSION: Because of its more anechoic appearance, PTR may be differentiated from the tumor by means of TRUS. This may lead to a statistically significantly higher accuracy of TRUS in the staging of rectal cancer due to the avoidance of overstaging.
Authors: Suk Hee Heo; Jin Woong Kim; Sang Soo Shin; Yong Yeon Jeong; Heoung-Keun Kang Journal: World J Gastroenterol Date: 2014-04-21 Impact factor: 5.742
Authors: Pietro Marone; Mario de Bellis; Valentina D'Angelo; Paolo Delrio; Valentina Passananti; Elena Di Girolamo; Giovanni Battista Rossi; Daniela Rega; Maura Claire Tracey; Alfonso Mario Tempesta Journal: World J Gastrointest Endosc Date: 2015-06-25
Authors: Daniela Kandioler; Ronald Zwrtek; Carmen Ludwig; Elisabeth Janschek; Meinhard Ploner; Friedrich Hofbauer; Irene Kührer; Sonja Kappel; Friedrich Wrba; Manfred Horvath; Josef Karner; Karl Renner; Michael Bergmann; Judith Karner-Hanusch; Richard Pötter; Raimund Jakesz; Bela Teleky; Friedrich Herbst Journal: Ann Surg Date: 2002-04 Impact factor: 12.969
Authors: G Brown; S Davies; G T Williams; M W Bourne; R G Newcombe; A G Radcliffe; J Blethyn; N S Dallimore; B I Rees; C J Phillips; T S Maughan Journal: Br J Cancer Date: 2004-07-05 Impact factor: 7.640