Literature DB >> 9169590

Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts.

C C Whiteford1, C A Brearley, E T Ulug.   

Abstract

PtdIns(3,5)P2 is identified as the product of an agonist-independent, wortmannin-sensitive pathway in resting mouse cells. Results are presented here to indicate that PtdIns(3,5)P2 is formed by phosphorylation of PtdIns3P at the D-5 position, and they suggest that relatively constant cellular levels of PtdIns3P and PtdIns(3, 5)P2 are maintained by the concerted action of PtdIns3P 5-kinase and PtdIns(3,5)P2 5-phosphatase. These studies imply a novel mechanism for the action of PtdIns-specific phosphoinositide 3-hydroxykinases in mammalian cells.

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Year:  1997        PMID： 9169590      PMCID： PMC1218360          DOI： 10.1042/bj3230597

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain.

Authors:  L A Serunian; M T Haber; T Fukui; J W Kim; S G Rhee; J M Lowenstein; L C Cantley
Journal:  J Biol Chem       Date:  1989-10-25       Impact factor: 5.157

Review 2.  Phosphoinositide 3-kinase and the regulation of cell growth.

Authors:  C L Carpenter; L C Cantley
Journal:  Biochim Biophys Acta       Date:  1996-08-08

3.  PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells.

Authors:  K R Auger; L A Serunian; S P Soltoff; P Libby; L C Cantley
Journal:  Cell       Date:  1989-04-07       Impact factor: 41.582

4.  L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells.

Authors:  L Stephens; P T Hawkins; N Carter; S B Chahwala; A J Morris; A D Whetton; P C Downes
Journal:  Biochem J       Date:  1988-01-01       Impact factor: 3.857

5.  Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen.

Authors:  E T Ulug; P T Hawkins; M R Hanley; S A Courtneidge
Journal:  J Virol       Date:  1990-08       Impact factor: 5.103

6.  Inositol phosphates in the duckweed Spirodela polyrhiza L.

Authors:  C A Brearley; D E Hanke
Journal:  Biochem J       Date:  1996-02-15       Impact factor: 3.857

7.  Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32P-labelled lipids from erythrocytes.

Authors:  P T Hawkins; R H Michell; C J Kirk
Journal:  Biochem J       Date:  1984-03-15       Impact factor: 3.857

8.  Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils.

Authors:  L R Stephens; K T Hughes; R F Irvine
Journal:  Nature       Date:  1991-05-02       Impact factor: 49.962

9.  Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase.

Authors:  P T Hawkins; T R Jackson; L R Stephens
Journal:  Nature       Date:  1992-07-09       Impact factor: 49.962

10.  Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland.

Authors:  C P Downes; P T Hawkins; R F Irvine
Journal:  Biochem J       Date:  1986-09-01       Impact factor: 3.857
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  43 in total

Review 1.  Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time.

Authors:  Natsuko Jin; Michael J Lang; Lois S Weisman
Journal:  Biochem Soc Trans       Date:  2016-02       Impact factor: 5.407

Review 2.  Phosphoinositides and vesicular membrane traffic.

Authors:  Peter Mayinger
Journal:  Biochim Biophys Acta       Date:  2012-01-14

3.  Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.

Authors:  Guy M Lenk; Miriam H Meisler
Journal:  Methods Enzymol       Date:  2014       Impact factor: 1.600

Review 4.  Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.

Authors:  Amber J McCartney; Yanling Zhang; Lois S Weisman
Journal:  Bioessays       Date:  2013-10-28       Impact factor: 4.345

5.  Visualization of Phosphatidylinositol 3,5-Bisphosphate Dynamics by a Tandem ML1N-Based Fluorescent Protein Probe in Arabidopsis.

Authors:  Tomoko Hirano; Kelly Stecker; Teun Munnik; Haoxing Xu; Masa H Sato
Journal:  Plant Cell Physiol       Date:  2017-07-01       Impact factor: 4.927

6.  Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes.

Authors:  Seyed Ali Mousavi; Andreas Brech; Trond Berg; Rune Kjeken
Journal:  Biochem J       Date:  2003-06-15       Impact factor: 3.857

Review 7.  The role of phosphoinositides in synapse function.

Authors:  Yoshibumi Ueda
Journal:  Mol Neurobiol       Date:  2014-06-17       Impact factor: 5.590

8.  Profiling lipid-protein interactions using nonquenched fluorescent liposomal nanovesicles and proteome microarrays.

Authors:  Kuan-Yi Lu; Sheng-Ce Tao; Tzu-Ching Yang; Yu-Hsuan Ho; Chia-Hsien Lee; Chen-Ching Lin; Hsueh-Fen Juan; Hsuan-Cheng Huang; Chin-Yu Yang; Ming-Shuo Chen; Yu-Yi Lin; Jin-Ying Lu; Heng Zhu; Chien-Sheng Chen
Journal:  Mol Cell Proteomics       Date:  2012-07-26       Impact factor: 5.911

9.  Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation.

Authors:  P P Ongusaha; P J Hughes; J Davey; R H Michell
Journal:  Biochem J       Date:  1998-11-01       Impact factor: 3.857

10.  Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.

Authors:  Yanling Zhang; Sergey N Zolov; Clement Y Chow; Shalom G Slutsky; Simon C Richardson; Robert C Piper; Baoli Yang; Johnathan J Nau; Randal J Westrick; Sean J Morrison; Miriam H Meisler; Lois S Weisman
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-23       Impact factor: 11.205
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