Literature DB >> 9169529

Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation.

A Lüthi1, H Van der Putten, F M Botteri, I M Mansuy, M Meins, U Frey, G Sansig, C Portet, M Schmutz, M Schröder, C Nitsch, J P Laurent, D Monard.   

Abstract

Protease nexin-1 (PN-1), a member of the serpin superfamily, controls the activity of extracellular serine proteases and is expressed in the brain. Mutant mice overexpressing PN-1 in brain under the control of the Thy-1 promoter (Thy 1/PN-1) or lacking PN-1 (PN-1-/-) were found to develop epileptic activity in vivo and in vitro. Theta burst-induced long-term potentiation (LTP) and NMDA receptor-mediated synaptic transmission in the CA1 field of hippocampal slices were augmented in Thy 1/PN-1 mice and reduced in PN-1-/- mice. Compensatory changes in GABA-mediated inhibition in Thy 1/PN-1 mice suggest that altered brain PN-1 levels lead to an imbalance between excitatory and inhibitory synaptic transmission.

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Year:  1997        PMID： 9169529      PMCID： PMC6573330     

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  82 in total

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