Literature DB >> 9168250

Microprobe X-ray absorption spectroscopic determination of the oxidation state of intracellular chromium following exposure of V79 Chinese hamster lung cells to genotoxic chromium complexes.

C T Dillon1, P A Lay, M Cholewa, G J Legge, A M Bonin, T J Collins, K L Kostka, G Shea-McCarthy.   

Abstract

The oxidation state of intracellular chromium has been determined directly in mammalian lung cells exposed to mutagenic and carcinogenic chromium compounds. Microprobe X-ray absorption spectroscopy (XAS) experiments on single V79 Chinese hamster lung cells showed that Cr(VI) and Cr(V) complexes were reduced completely (>90%) to Cr(III) within 4 h of exposure of the cells. This result provides direct evidence for the hypothesis that these genotoxic oxidants react rapidly with intracellular reductants.

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Year:  1997        PMID： 9168250     DOI： 10.1021/tx970010m

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  9 in total

1.  The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells.

Authors:  Matthew D Hall; Carolyn T Dillon; Mei Zhang; Philip Beale; Zhonghou Cai; Barry Lai; Anton P J Stampfl; Trevor W Hambley
Journal:  J Biol Inorg Chem       Date:  2003-07-12       Impact factor: 3.358

2.  Time-dependent uptake, distribution and biotransformation of chromium(VI) in individual and bulk human lung cells: application of synchrotron radiation techniques.

Authors:  Hugh H Harris; Aviva Levina; Carolyn T Dillon; Irma Mulyani; Barry Lai; Zhonghou Cai; Peter A Lay
Journal:  J Biol Inorg Chem       Date:  2005-02-16       Impact factor: 3.358

3.  Binding of chromium(VI) to histones: implications for chromium(VI)-induced genotoxicity.

Authors:  Aviva Levina; Hugh H Harris; Peter A Lay
Journal:  J Biol Inorg Chem       Date:  2005-12-15       Impact factor: 3.358

4.  Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolism.

Authors:  David Guttmann; Graham Poage; Tatiana Johnston; Anatoly Zhitkovich
Journal:  Chem Res Toxicol       Date:  2008-11       Impact factor: 3.739

5.  Cr(III)-mediated crosslinks of glutathione or amino acids to the DNA phosphate backbone are mutagenic in human cells.

Authors:  V Voitkun; A Zhitkovich; M Costa
Journal:  Nucleic Acids Res       Date:  1998-04-15       Impact factor: 16.971

6.  Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.

Authors:  Sarmila Majumder; Kalpana Ghoshal; Dennis Summers; Shoumei Bai; Jharna Datta; Samson T Jacob
Journal:  J Biol Chem       Date:  2003-04-25       Impact factor: 5.157

Review 7.  Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium.

Authors:  Konstantin Salnikow; Anatoly Zhitkovich
Journal:  Chem Res Toxicol       Date:  2007-10-30       Impact factor: 3.739

8.  Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair.

Authors:  Mindy Reynolds; Lauren Stoddard; Ivan Bespalov; Anatoly Zhitkovich
Journal:  Nucleic Acids Res       Date:  2006-12-14       Impact factor: 16.971

9.  Utilization of DNA-protein cross-links as a biomarker of chromium exposure.

Authors:  A Zhitkovich; V Voitkun; T Kluz; M Costa
Journal:  Environ Health Perspect       Date:  1998-08       Impact factor: 9.031
  9 in total

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