BACKGROUND: Metastatic uterine low-grade smooth-muscle tumors may present with pulmonary symptoms and radiographic lung abnormalities consistent with metastatic neoplasms. Ovarian hormone stimulation of these smooth-muscle tumors has been suggested, but the role of surgical or medical oophorectomy has not been established in patients with metastatic disease. CASES: Two women with histologically confirmed uterine low-grade smooth-muscle tumors metastatic to the lung had progressive and complete tumor regression after oophorectomy and no further therapy. CONCLUSION: Some uterine low-grade smooth-muscle tumors metastatic to the lung regress after oophorectomy. Removing ovarian hormone stimulation may result in complete tumor regression without the need for further therapy.
BACKGROUND: Metastatic uterine low-grade smooth-muscle tumors may present with pulmonary symptoms and radiographic lung abnormalities consistent with metastatic neoplasms. Ovarian hormone stimulation of these smooth-muscle tumors has been suggested, but the role of surgical or medical oophorectomy has not been established in patients with metastatic disease. CASES: Two women with histologically confirmed uterine low-grade smooth-muscle tumors metastatic to the lung had progressive and complete tumor regression after oophorectomy and no further therapy. CONCLUSION: Some uterine low-grade smooth-muscle tumors metastatic to the lung regress after oophorectomy. Removing ovarian hormone stimulation may result in complete tumor regression without the need for further therapy.
Authors: Young-Il Kwon; Tae-Hyung Kim; Jang Won Sohn; Ho Joo Yoon; Dong Ho Shin; Sung Soo Park Journal: Korean J Intern Med Date: 2006-09 Impact factor: 2.884
Authors: Erin I Lewis; Rebecca J Chason; Alan H DeCherney; Alicia Armstrong; John Elkas; Aradhana M Venkatesan Journal: Fertil Steril Date: 2013-03-05 Impact factor: 7.329
Authors: Ambrogio P Londero; Patrizia Perego; Costantino Mangioni; Ralph J Lellé; Franco Londero; Diego Marchesoni Journal: J Med Case Rep Date: 2008-09-23