Literature DB >> 9166207

The levonorgestrel intrauterine system in the management of menorrhagia.

J W Barrington1, P Bowen-Simpkins.   

Abstract

OBJECTIVE: To assess the effect of a levonorgestrel releasing intrauterine system in the management of menorrhagia.
DESIGN: A prospective study.
SETTING: A district general hospital in South Wales.
METHODS: Fifty women with a failed trial of medical therapy and awaiting hysterectomy or transcervical resection of the endometrium (TCRE) were treated with a levonorgestrel intrauterine system. The menstrual loss was estimated using a modified pictorial chart together with a full blood count and ferritin measurement preinsertion and at three and six to nine months postinsertion.
RESULTS: The menstrual loss was reduced to acceptable levels in 37 women at three months and a further four by six to nine months. In all, 41 patients were taken off the waiting list for surgery, four of whom became amenorrhoeic. There was no significant change in full blood count nor ferritin measurement despite unscheduled bleeding for six to eight weeks postinsertion. Fifty-six percent of patients noticed considerable improvement or cure of their premenstrual syndrome symptoms; 80% noted a reduction in dysmenorrhoea.
CONCLUSION: The levonorgestrel releasing intrauterine system is an effective nonsurgical treatment for the management of menorrhagia and dysmenorrhoea that has additional benefit as a contraceptive and in relieving premenstrual syndrome.

Entities:  

Keywords:  Contraception; Contraceptive Agents, Female--therapeutic use; Contraceptive Agents, Progestin--therapeutic use; Contraceptive Agents--therapeutic use; Contraceptive Methods--therapeutic use; Developed Countries; Diseases; Dysmenorrhea; Europe; Family Planning; Iud, Hormone Releasing--therapeutic use; Iud--therapeutic use; Levonorgestrel--therapeutic use; Menorrhagia; Menstruation Disorders; Northern Europe; Prospective Studies; Research Methodology; Research Report; Studies; Treatment; United Kingdom; Wales

Mesh:

Substances:

Year:  1997        PMID: 9166207     DOI: 10.1111/j.1471-0528.1997.tb11542.x

Source DB:  PubMed          Journal:  Br J Obstet Gynaecol        ISSN: 0306-5456


  18 in total

Review 1.  Fortnightly review. Medical management of menorrhagia.

Authors:  A Prentice
Journal:  BMJ       Date:  1999-11-20

Review 2.  Recent advances. Gynaecology.

Authors:  C Kelleher; P Braude
Journal:  BMJ       Date:  1999-09-11

Review 3.  The levonorgestrel-releasing intrauterine system in heavy menstrual bleeding: a benefit-risk review.

Authors:  Andrew M Kaunitz; Pirjo Inki
Journal:  Drugs       Date:  2012-01-22       Impact factor: 9.546

4.  Medical management of menorrhagia.

Authors:  A Prentice
Journal:  West J Med       Date:  2000-04

5.  Open randomised study of use of levonorgestrel releasing intrauterine system as alternative to hysterectomy.

Authors:  P Lähteenmäki; M Haukkamaa; J Puolakka; U Riikonen; S Sainio; J Suvisaari; C G Nilsson
Journal:  BMJ       Date:  1998-04-11

6.  Comparative analysis of changes in MR imaging of pre and post intrauterine progesterone implants in adenomyosis cases.

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Review 7.  The role of hormones and hormonal treatments in premenstrual syndrome.

Authors:  Torbjörn Bäckström; Lotta Andreen; Vita Birzniece; Inger Björn; Inga-Maj Johansson; Maud Nordenstam-Haghjo; Sigrid Nyberg; Inger Sundström-Poromaa; Göran Wahlström; Mingde Wang; Di Zhu
Journal:  CNS Drugs       Date:  2003       Impact factor: 5.749

8.  The evidence is in. Why are IUDs still out?: family physicians' perceptions of risk and indications.

Authors:  Esther Stubbs; Adrianna Schamp
Journal:  Can Fam Physician       Date:  2008-04       Impact factor: 3.275

Review 9.  Benefits and risks of pharmacological agents used for the treatment of menorrhagia.

Authors:  Samendra Nath Roy; Siladitya Bhattacharya
Journal:  Drug Saf       Date:  2004       Impact factor: 5.606

Review 10.  Abnormal uterine bleeding: a review of patient-based outcome measures.

Authors:  Kristen A Matteson; Lori A Boardman; Malcolm G Munro; Melissa A Clark
Journal:  Fertil Steril       Date:  2008-07-16       Impact factor: 7.329

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