Literature DB >> 9165072

Feedback inhibition of dihydrodipicolinate synthase enzymes by L-lysine.

S Blickling1, J Knäblein.   

Abstract

Dihydrodipicolinate synthase (DHDPS) is the first enzyme unique to the lysine biosynthetic pathway and is feedback regulated by L-lysine in plants and some bacteria. The allosteric binding site has been localized by X-ray crystallography and is in agreement with reported mutations of plant DHDPS enzymes, which confer insensitivity to feedback inhibition. Three possible elements of the mechanism of lysine inhibition are discussed.

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Year:  1997        PMID： 9165072     DOI： 10.1515/bchm.1997.378.3-4.207

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   3.915


  8 in total

1.  Mimicking natural evolution in vitro: an N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity.

Authors:  Andreas C Joerger; Sebastian Mayer; Alan R Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-23       Impact factor: 11.205

2.  Structure of the 4-hydroxy-tetrahydrodipicolinate synthase from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV and the phylogeny of the aminotransferase pathway.

Authors:  Rob A Schmitz; Andreas Dietl; Melanie Müller; Tom Berben; Huub J M Op den Camp; Thomas R M Barends
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2020-04-28       Impact factor: 1.056

3.  Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica.

Authors:  Jacinta M Wubben; Con Dogovski; Renwick C J Dobson; Rachel Codd; Juliet A Gerrard; Michael W Parker; Matthew A Perugini
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-10-29

4.  Adaptation to a new environment allows cooperators to purge cheaters stochastically.

Authors:  Adam James Waite; Wenying Shou
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-22       Impact factor: 11.205

5.  Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 Å resolution.

Authors:  Kubra F Naqvi; Bart L Staker; Renwick C J Dobson; Dmitry Serbzhinskiy; Banumathi Sankaran; Peter J Myler; André O Hudson
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2016-01-01       Impact factor: 1.056

6.  Overproduction of L-Lysine from methanol by Methylobacillus glycogenes derivatives carrying a plasmid with a mutated dapA gene.

Authors:  H Motoyama; H Yano; Y Terasaki; H Anazawa
Journal:  Appl Environ Microbiol       Date:  2001-07       Impact factor: 4.792

7.  The Hidden Potential of High-Throughput RNA-Seq Re-Analysis, a Case Study for DHDPS, Key Enzyme of the Aspartate-Derived Lysine Biosynthesis Pathway and Its Role in Abiotic and Biotic Stress Responses in Soybean.

Authors:  Raphaël Kiekens; Ramon de Koning; Mary Esther Muyoka Toili; Geert Angenon
Journal:  Plants (Basel)       Date:  2022-07-01

8.  Characterisation of the first enzymes committed to lysine biosynthesis in Arabidopsis thaliana.

Authors:  Michael D W Griffin; Jagan M Billakanti; Akshita Wason; Sabrina Keller; Haydyn D T Mertens; Sarah C Atkinson; Renwick C J Dobson; Matthew A Perugini; Juliet A Gerrard; Frederick Grant Pearce
Journal:  PLoS One       Date:  2012-07-05       Impact factor: 3.240
  8 in total

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