Persistence of humoral immunity to rabies 1100 days after immunization and effect of a single booster dose of rabies vaccine.

Forty-four vaccinees immunized with rabies vaccine and human rabies immunoglobulin according to the abbreviated intramuscular regimen (the 2-1-1 schedule) were followed-up after 1100 days and had their blood samples taken. The persistence of rabies neutralizing antibody was proven in the sera of all vaccinees. 56% of whom demonstrated titres > or = 0.5 IU ml-1. At the same day the vaccinees were given a single booster dose of vaccine whose effect was measured 2 weeks later. With the RFFI test on day 1114, sera revealed an extraordinarily high booster response in all 44 vaccinees. The study proved the anamnestic response after a full course of rabies vaccination to be a very stable one, and the capability of a single booster dose of vaccine to evoke high-titred rabies antibody response. Of the four vaccines used in the study, under comparable conditions HDCV proved superior to PCECV PDEV and PVRV on all 3 days of serology-35, 1100 and 1114, though this difference was statistically attested only on days 35 and 1114.

RCT Entities:   Population Interventions Outcomes