Literature DB >> 9159163

Localized gene action controlling intestinal neoplasia in mice.

K A Gould1, W F Dove.   

Abstract

Mice heterozygous for the ApcMin (Min) mutation develop adenomas throughout the intestinal tract. Apc is believed to be involved in cell migration, adhesion, and polarity. Adenoma multiplicity and growth rate are modulated by an unlinked modifier locus, Mom1. The secretory phospholipase Pla2g2a is a candidate for Mom1. Here, we investigate the range of action of Apc and Mom1. Analysis of chimeric Min mice indicates that the actions of both Apc and Mom1 are localized within the cell lineage that gives rise to intestinal tumors.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9159163      PMCID： PMC20869          DOI： 10.1073/pnas.94.11.5848

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  35 in total

Review 1.  Studies of neoplasia in the Min mouse.

Authors:  A R Shoemaker; K A Gould; C Luongo; A R Moser; W F Dove
Journal:  Biochim Biophys Acta       Date:  1997-04-18

2.  Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types.

Authors:  H Cheng; C P Leblond
Journal:  Am J Anat       Date:  1974-12

3.  Cell migration pathway in the intestinal epithelium: an in situ marker system using mouse aggregation chimeras.

Authors:  G H Schmidt; M M Wilkinson; B A Ponder
Journal:  Cell       Date:  1985-02       Impact factor: 41.582

4.  Action of Min and Mom1 on neoplasia in ectopic intestinal grafts.

Authors:  K A Gould; W F Dove
Journal:  Cell Growth Differ       Date:  1996-10

5.  Multiclonal origin of polyps in Gardner syndrome.

Authors:  S H Hsu; G D Luk; A J Krush; S R Hamilton; H H Hoover
Journal:  Science       Date:  1983-09-02       Impact factor: 47.728

6.  The kinetics of villus cell populations in the mouse small intestine. I. Normal villi: the steady state requirement.

Authors:  N A Wright; M Irwin
Journal:  Cell Tissue Kinet       Date:  1982-11

7.  Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.

Authors:  K A Gould; C Luongo; A R Moser; M K McNeley; N Borenstein; A Shedlovsky; W F Dove; K Hong; W F Dietrich; E S Lander
Journal:  Genetics       Date:  1996-12       Impact factor: 4.562

8.  Derivation of mouse intestinal crypts from single progenitor cells.

Authors:  B A Ponder; G H Schmidt; M M Wilkinson; M J Wood; M Monk; A Reid
Journal:  Nature       Date:  1985 Feb 21-27       Impact factor: 49.962

9.  Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium.

Authors:  M H Wong; M L Hermiston; A J Syder; J I Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-03       Impact factor: 11.205

10.  Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

Authors:  J R Sanes; J L Rubenstein; J F Nicolas
Journal:  EMBO J       Date:  1986-12-01       Impact factor: 11.598
View more
  12 in total

1.  Epithelial stem cell repertoire in the gut: clues to the origin of cell lineages, proliferative units and cancer.

Authors:  N A Wright
Journal:  Int J Exp Pathol       Date:  2000-04       Impact factor: 1.925

Review 2.  Tissue architecture: the ultimate regulator of epithelial function?

Authors:  C Hagios; A Lochter; M J Bissell
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1998-06-29       Impact factor: 6.237

Review 3.  Animal models of human genetic diseases: do they need to be faithful to be useful?

Authors:  Jean-Louis Guénet
Journal:  Mol Genet Genomics       Date:  2011-05-06       Impact factor: 3.291

4.  Diversity in secreted PLA2-IIA activity among inbred mouse strains that are resistant or susceptible to Apc Min/+ tumorigenesis.

Authors:  Marina Markova; Revati A Koratkar; Karen A Silverman; Vincent E Sollars; Melina MacPhee-Pellini; Rhonda Walters; Juan P Palazzo; Arthur M Buchberg; Linda D Siracusa; Steven A Farber
Journal:  Oncogene       Date:  2005-09-22       Impact factor: 9.867

5.  Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras.

Authors:  M R Novelli; H Wasan; I Rosewell; J Bee; I P Tomlinson; N A Wright; W F Bodmer
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

6.  The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells.

Authors:  Emmelie A Jansson; Alexandra Are; Gediminas Greicius; I-Chun Kuo; Denise Kelly; Velmurugesan Arulampalam; Sven Pettersson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-21       Impact factor: 11.205

7.  Transformation of epithelial cells through recruitment leads to polyclonal intestinal tumors.

Authors:  Andrew T Thliveris; Brittany Schwefel; Linda Clipson; Lauren Plesh; Christopher D Zahm; Alyssa A Leystra; Mary Kay Washington; Ruth Sullivan; Dustin A Deming; Michael A Newton; Richard B Halberg
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-24       Impact factor: 11.205

8.  Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53.

Authors:  H Nozawa; E Oda; K Nakao; M Ishihara; S Ueda; T Yokochi; K Ogasawara; Y Nakatsuru; S Shimizu; Y Ohira; K Hioki; S Aizawa; T Ishikawa; M Katsuki; T Muto; T Taniguchi; N Tanaka
Journal:  Genes Dev       Date:  1999-05-15       Impact factor: 11.361

Review 9.  The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions.

Authors:  W F Dove; R T Cormier; K A Gould; R B Halberg; A J Merritt; M A Newton; A R Shoemaker
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1998-06-29       Impact factor: 6.237

10.  Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture.

Authors:  J L Tsao; J Zhang; R Salovaara; Z H Li; H J Järvinen; J P Mecklin; L A Aaltonen; D Shibata
Journal:  Am J Pathol       Date:  1998-10       Impact factor: 4.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.