Literature DB >> 9158865

3N-methylbiphenylsulfonylurea and -carbamate substituted imidazo[4,5-b]pyridines. Potent antagonists of the ANG II AT1 receptors.

H Heitsch1, R H Becker, H W Kleemann, A Wagner.   

Abstract

The synthesis and the SAR study of imidazo[4,5-b]pyridine biphenyl sulfonylureas and -carbamates as highly potent AT1-selective ANG II receptor antagonists are described. Several members of this new class of antagonists efficiently inhibited the ANG II-induced pressor response in pithed rats after iv and intraduodenal (id) administration.

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Year:  1997        PMID： 9158865     DOI： 10.1016/s0968-0896(97)00012-6

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  Iron oxide (Fe3O4) magnetic nanoparticles supported on wrinkled fibrous nanosilica (WFNS) functionalized by biimidazole ionic liquid as an effective and reusable heterogeneous magnetic nanocatalyst for the efficient synthesis of N-sulfonylamidines.

Authors:  Sajjad Azizi; Nasrin Shadjou
Journal:  Heliyon       Date:  2021-01-28

2.  Regioselective synthesis of heterocyclic N-sulfonyl amidines from heteroaromatic thioamides and sulfonyl azides.

Authors:  Vladimir Ilkin; Vera Berseneva; Tetyana Beryozkina; Tatiana Glukhareva; Lidia Dianova; Wim Dehaen; Eugenia Seliverstova; Vasiliy Bakulev
Journal:  Beilstein J Org Chem       Date:  2020-12-01       Impact factor: 2.883

3.  Rapid and efficient synthesis of formamidines in a catalyst-free and solvent-free system.

Authors:  Zitong Zhou; Yu Zhao; Donghua Zhou; Li Li; Hui Luo; Liao Cui; Weiguang Yang
Journal:  RSC Adv       Date:  2021-10-18       Impact factor: 4.036
  3 in total

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