M Coutard1, M Osborne-Pellegrin. 1. Institut National de la Santé et de la Recherche Médicale, INSERM U 367, Paris, France.
Abstract
BACKGROUND AND PURPOSE: The susceptibility to experimental cerebral aneurysm formation in arteries of the circle of Willis was studied in four strains of rats presenting different susceptibilities to the spontaneous rupture of the internal elastic lamina in extracerebral arteries: Brown-Norway (BN) > Wistar > Long-Evans (LE) > LOU. METHODS: Rats (150 g body weight) of the four strains were subjected to hypertension and a change in local cerebral blood flow by ligation of one common carotid artery for about 7 months. Six-month-old BN and LE rats were subjected to carotid ligation only for 11 to 13.5 months and treated or not (from 3 to 7 months of age) with an inhibitor of connective tissue fiber maturation, beta-aminopropionitrile (BAPN). RESULTS: Aneurysmal structures (AS) occurred mainly in the anterior cerebral/anterior communicating arterial complex and proximal part of the posterior artery. In hypertensive rats, the AS incidence was LE, 56%; Wistar, 33%; BN, 17%; and LOU, 11%. When normotensive and subjected to carotid ligation only, LE rats showed an even greater susceptibility to AS formation (86%) than BN (7%). BAPN treatment did not influence AS formation: LE (60%) versus BN (8%). CONCLUSIONS: These results suggest that genetic factors are involved in cerebral aneurysm formation in the rat. The susceptibility of the internal elastic lamina of extracerebral arteries to spontaneous rupture does not appear to be a determinant genetic trait in the propensity to develop aneurysms in arteries of the circle of Willis. The comparison of these different rat strains may be very useful for studying factors contributing to cerebral aneurysm pathogenesis.
BACKGROUND AND PURPOSE: The susceptibility to experimental cerebral aneurysm formation in arteries of the circle of Willis was studied in four strains of rats presenting different susceptibilities to the spontaneous rupture of the internal elastic lamina in extracerebral arteries: Brown-Norway (BN) > Wistar > Long-Evans (LE) > LOU. METHODS:Rats (150 g body weight) of the four strains were subjected to hypertension and a change in local cerebral blood flow by ligation of one common carotid artery for about 7 months. Six-month-old BN and LErats were subjected to carotid ligation only for 11 to 13.5 months and treated or not (from 3 to 7 months of age) with an inhibitor of connective tissue fiber maturation, beta-aminopropionitrile (BAPN). RESULTS:Aneurysmal structures (AS) occurred mainly in the anterior cerebral/anterior communicating arterial complex and proximal part of the posterior artery. In hypertensiverats, the AS incidence was LE, 56%; Wistar, 33%; BN, 17%; and LOU, 11%. When normotensive and subjected to carotid ligation only, LErats showed an even greater susceptibility to AS formation (86%) than BN (7%). BAPN treatment did not influence AS formation: LE (60%) versus BN (8%). CONCLUSIONS: These results suggest that genetic factors are involved in cerebral aneurysm formation in the rat. The susceptibility of the internal elastic lamina of extracerebral arteries to spontaneous rupture does not appear to be a determinant genetic trait in the propensity to develop aneurysms in arteries of the circle of Willis. The comparison of these different rat strains may be very useful for studying factors contributing to cerebral aneurysm pathogenesis.
Authors: Vincent Matthew Tutino; Nicholas Liaw; Joseph Andrew Spernyak; Ciprian Nicolae Ionita; Adnan Hussain Siddiqui; John Kolega; Hui Meng Journal: Curr Neurovasc Res Date: 2016 Impact factor: 1.990
Authors: Vincent M Tutino; Hamidreza Rajabzadeh-Oghaz; Sricharan S Veeturi; Kerry E Poppenberg; Muhammad Waqas; Max Mandelbaum; Nicholas Liaw; Adnan H Siddiqui; Hui Meng; John Kolega Journal: Neurosurg Rev Date: 2021-01-26 Impact factor: 2.800