H Bokura1, R G Robinson. 1. Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242-1057, USA.
Abstract
BACKGROUND AND PURPOSE: Neuropsychiatric findings were examined in 91 patients with acute focal subcortical lesions to determine whether cognitive outcome would differ depending on whether the head of the caudate or other subcortical structures were injured. METHODS: Patients were evaluated using the Mini-Mental State Examination (MMSE), Hamilton Rating Scale for Depression, and modified Present State Examination. Patients were reexamined at short-term (3 to 6 months) or long-term (1 to 2 years) follow-up. RESULTS: There were no significant intergroup differences in the MMSE scores at the initial evaluation or at short-term follow-up. At long-term follow-up, however, patients with either right or left caudate lesions had significantly lower MMSE scores than patients with other subcortical lesions. CONCLUSIONS: A significant number of patients with caudate infarction deteriorate in their intellectual function between 1 and 2 years after stroke. This phenomenon could be mediated through disruption of cortical projections to the caudate.
BACKGROUND AND PURPOSE: Neuropsychiatric findings were examined in 91 patients with acute focal subcortical lesions to determine whether cognitive outcome would differ depending on whether the head of the caudate or other subcortical structures were injured. METHODS:Patients were evaluated using the Mini-Mental State Examination (MMSE), Hamilton Rating Scale for Depression, and modified Present State Examination. Patients were reexamined at short-term (3 to 6 months) or long-term (1 to 2 years) follow-up. RESULTS: There were no significant intergroup differences in the MMSE scores at the initial evaluation or at short-term follow-up. At long-term follow-up, however, patients with either right or left caudate lesions had significantly lower MMSE scores than patients with other subcortical lesions. CONCLUSIONS: A significant number of patients with caudate infarction deteriorate in their intellectual function between 1 and 2 years after stroke. This phenomenon could be mediated through disruption of cortical projections to the caudate.
Authors: Min-Seong Koo; James J Levitt; Robert W McCarley; Larry J Seidman; Chandlee C Dickey; Margaret A Niznikiewicz; Martina M Voglmaier; Payman Zamani; Katherine R Long; Sunnie S Kim; Martha E Shenton Journal: Biol Psychiatry Date: 2006-02-07 Impact factor: 13.382
Authors: Madalena Esteves; Pedro S Moreira; Paulo Marques; Teresa C Castanho; Ricardo Magalhães; Liliana Amorim; Carlos Portugal-Nunes; José M Soares; Ana Coelho; Armando Almeida; Nadine C Santos; Nuno Sousa; Hugo Leite-Almeida Journal: Aging Cell Date: 2018-12-21 Impact factor: 9.304