Literature DB >> 915747

Fluorometric determination of methyldopa in biological fluids.

B K Kim, R T Koda.   

Abstract

A fluorometric method for the analysis of methyldopa, based on the formation of a fluorophore after oxidation and rearrangement, is described. The drug is isolated from biological fluids by adsorption on alumina and elution with an organic solvent. Fluoresence is linear from 0.1 to 1.5 microgram of methyldopa/ml. The assay has a lower limit of sensitivity of 100 ng/ml and is suitable for pharmacokinetic studies following therapeutic doses in animals and humans.

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Year:  1977        PMID： 915747     DOI： 10.1002/jps.2600661135

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  2 in total

1.  Comparative bioavailability of alpha-methyldopa normal and film tablet formulations after single oral administration in healthy volunteers.

Authors:  K Róna; K Ary; G Renczes; B Gachályi; G Y Grézal; S Drabant; I Klebovich
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2001 Jan-Jun       Impact factor: 2.441

2.  Toward the understanding of the metabolism of levodopa I. DFT investigation of the equilibrium geometries, acid-base properties and levodopa-water complexes.

Authors:  Shabaan A K Elroby; Mohamed S I Makki; Tariq R Sobahi; Rifaat H Hilal
Journal:  Int J Mol Sci       Date:  2012-04-02       Impact factor: 6.208
  2 in total

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