| Literature DB >> 915740 |
L Teng, R B Bruce, L K Dunning.
Abstract
A high-pressure liquid chromatographic method suitable for determining plasma metoclopramide levels at normal (10-20 mg) doses is described. Eight metabolites as well as metclopramide were isolated and identified in rat, dog. and human urine. The only common metabolite in these species is 2-[(4-amino-5-chloro-2-methoxybenzoyl)-amino] acetic acid. N-Deethylation is a major pathway for metoclopramide metabolism in the lower animals but not in humans. Metoclopramide is excreted mainly unchanged or as its conjugates by humans.Entities:
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Year: 1977 PMID： 915740 DOI： 10.1002/jps.2600661128
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534