Literature DB >> 9151213

Triplex DNA: fundamentals, advances, and potential applications for gene therapy.

P P Chan1, P M Glazer.   

Abstract

The ability to target specific sequences of DNA through oligonucleotide-based triple-helix formation provides a powerful tool for genetic manipulation. Under experimental conditions, triplex DNA can inhibit DNA transcription and replication, generate site-specific mutations, cleave DNA, and induce homologous recombination. This review describes the binding requirements for triplex formation, surveys recent advancements in the chemistry and biology of triple helices and considers several potential applications of triplex DNA for use in genetic therapy.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9151213     DOI： 10.1007/s001090050112

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  55 in total

1.  Optimization of alternate-strand triple helix formation at the 5"-TpA-3" and 5"-ApT-3" junctions.

Authors:  P Brodin; J S Sun; J F Mouscadet; C Auclair
Journal:  Nucleic Acids Res       Date:  1999-08-01       Impact factor: 16.971

2.  The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

Authors:  H Zan; A Komori; Z Li; A Cerutti; A Schaffer; M F Flajnik; M Diaz; P Casali
Journal:  Immunity       Date:  2001-05       Impact factor: 31.745

3.  Quantitative assessment of chimeraplast stability in biological fluids by polyacrylamide gel electrophoresis and laser-assisted fluorescence analysis.

Authors:  David de Semir; Anna Avinyó; Sara Larriba; Virginia Nunes; Teresa Casals; Xavier Estivill; Josep M Aran
Journal:  Pharm Res       Date:  2002-06       Impact factor: 4.200

4.  Repairing the Sickle Cell mutation. II. Effect of psoralen linker length on specificity of formation and yield of third strand-directed photoproducts with the mutant target sequence.

Authors:  Olga Amosova; Steven L Broitman; Jacques R Fresco
Journal:  Nucleic Acids Res       Date:  2003-08-15       Impact factor: 16.971

5.  Triplex forming oligonucleotide targeted to 3'UTR downregulates the expression of the bcl-2 proto-oncogene in HeLa cells.

Authors:  C Shen; A Buck; G Mehrke; B Polat; H Gross; M Bachem; S Reske
Journal:  Nucleic Acids Res       Date:  2001-02-01       Impact factor: 16.971

6.  Mechanism of copper mediated triple helix formation at neutral pH in Drosophila satellite repeats.

Authors:  C Paris; F Geinguenaud; C Gouyette; J Liquier; J Lacoste
Journal:  Biophys J       Date:  2007-01-05       Impact factor: 4.033

7.  Chemotherapeutic deletion of CTG repeats in lymphoblast cells from DM1 patients.

Authors:  Vera I Hashem; Malgorzata J Pytlos; Elzbieta A Klysik; Kuniko Tsuji; Mehrdad Khajavi; Merhdad Khajav; Tetsuo Ashizawa; Richard R Sinden
Journal:  Nucleic Acids Res       Date:  2004-12-01       Impact factor: 16.971

8.  Evaluation of effects of bivalent cations on the formation of purine-rich triple-helix DNA by ESI-FT-MS.

Authors:  Cuihong Wan; Meng Cui; Fengrui Song; Zhiqiang Liu; Shuying Liu
Journal:  J Am Soc Mass Spectrom       Date:  2009-02-25       Impact factor: 3.109

9.  Transplatin-conjugated triplex-forming oligonucleotides form adducts with both strands of DNA.

Authors:  Meghan A Campbell; Paul S Miller
Journal:  Bioconjug Chem       Date:  2009-12       Impact factor: 4.774

10.  Determination of DNA guanine sites forming photo-adducts with Ru(II)-labeled oligonucleotides; DNA polymerase inhibition by the resulting photo-crosslinking.

Authors:  Olivier Lentzen; Eric Defrancq; Jean-François Constant; Stephan Schumm; David García-Fresnadillo; Cécile Moucheron; Pascal Dumy; Andrée Kirsch-De Mesmaeker
Journal:  J Biol Inorg Chem       Date:  2003-12-04       Impact factor: 3.358
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.