Borders and topographic relationships of the paraglottic space.

The precise topographic relationships of the paraglottic space (PGS) were investigated in serial plastinated or frozen whole-organ sections of 46 normal adult larynges. Laterally, the PGS was bordered by the thyroid cartilage. Superomedially, the PGS in some specimens was only separated from the periepiglottic space by a coherent collagenous fiber septum. The paraglottic adipose tissue extended between the caudal fibers of the thyroarytenoid muscle. Inferomedially, the PGS was bordered by the conus elasticus. The anteroinferior portion of the PGS extended beyond the larynx beneath the inferior rim of the thyroid cartilage. Posteroinferiorly, the paraglottic adipose tissue extended towards the cricoarytenoid joint. Dorsally, the PGS was bordered by the mucosal lining of the piriform sinus. Due to the intimate topographic and histologic relationships present, cancer involving the PGS may rapidly infiltrate all adjacent anatomic structures.