| Literature DB >> 91505 |
Abstract
The authors examined the effects of 3-aminopyridine (3-AP) on pyramidal tract neurones in the motor cortex of anesthetised cats. 3-AP proved to be a strong convulsive agent. Local application of 3-AP in concentrations of 15-20 mM resulted in typical paroxysmal alterations of neuronal activity: (a) enhancement of background firing, (b) augmentation of EPSPs, (c) depression of IPSPs and (d) single and serial paroxysmal depolarization shifts (PDSs). Serial PDSs were reflected by large synchronous waves in the surface ECoG.Entities:
Mesh：
Substances：
Year: 1979 PMID： 91505 DOI： 10.1016/0013-4694(79)90303-1
Source DB: PubMed Journal: Electroencephalogr Clin Neurophysiol ISSN： 0013-4694