Literature DB >> 9149293

Intracisternal TRH and RX 77368 potently activate gastric vagal efferent discharge in rats.

T J O-Lee1, J Y Wei, Y Taché.   

Abstract

The influence of intracisternal (ic) TRH and the stable TRH analog, RX 77368, on gastric vagal efferent discharge (GVED) was investigated in urethane-anesthetized rats. Consecutive IC injections of TRH (3, 30, and 300 ng) at 60 min intervals stimulated dose dependently multi-unit GVED with a peak increase of 90 +/- 21%, 127 +/- 18% and 145 +/- 16% respectively. In two separate studies, IC injection of RX 77368 at 1.5 or 15 ng stimulated multi-unit GVED by 142 +/- 24% and 244 +/- 95% respectively. Saline injection IC had no effect on GVED. RX 77368 (1.5 ng, ic) action was long lasting (84 +/- 13 min) compared with TRH (3 ng: 44 +/- 7 min). Single-unit analysis also showed that 13 of 13 units responded to ic RX 77368 (1.5 ng) by an increase in activity. These data indicate that low doses of TRH injected ic stimulate vagal efferent outflow to the rat stomach and that RX 77368 action is more potent than TRH.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9149293     DOI： 10.1016/s0196-9781(96)00281-1

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  11 in total

1.  Acute cold exposure induces vagally mediated Fos expression in gastric myenteric neurons in conscious rats.

Authors:  P Q Yuan; Y Taché; M Miampamba; H Yang
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2001-08       Impact factor: 4.052

Review 2.  Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents.

Authors:  Y Tache
Journal:  Curr Med Chem       Date:  2012       Impact factor: 4.530

3.  Central vagal stimulation activates enteric cholinergic neurons in the stomach and VIP neurons in the duodenum in conscious rats.

Authors:  Pu-Qing Yuan; Hiroshi Kimura; Mulugeta Million; Jean-Pierre Bellier; Lixin Wang; Gordon V Ohning; Yvette Taché
Journal:  Peptides       Date:  2005-01-06       Impact factor: 3.750

4.  Pattern-dependent vagal control of gastric secretion: the role of histamine mediation.

Authors:  V A Zolotarev; R P Khropycheva; S A Polenov
Journal:  Dokl Biol Sci       Date:  2005 Mar-Apr

Review 5.  Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding.

Authors:  Y Taché; H Yang; M Miampamba; V Martinez; P Q Yuan
Journal:  Auton Neurosci       Date:  2006-03-06       Impact factor: 3.145

6.  Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats.

Authors:  Andreas Stengel; Miriam Goebel; Andrew Luckey; Pu-Qing Yuan; Lixin Wang; Yvette Taché
Journal:  Peptides       Date:  2010-09-15       Impact factor: 3.750

7.  Brain-gut interactions between central vagal activation and abdominal surgery to influence gastric myenteric ganglia Fos expression in rats.

Authors:  Marcel Miampamba; Mulugeta Million; Yvette Taché
Journal:  Peptides       Date:  2011-03-02       Impact factor: 3.750

8.  Hypothyroidism induces Fos-like immunoreactivity in ventral medullary neurons that synthesize TRH.

Authors:  P Q Yuan; H Yang
Journal:  Am J Physiol       Date:  1999-11

9.  Localization of thyroid hormone receptor beta2 in the ventral medullary neurons that synthesize thyrotropin-releasing hormone.

Authors:  P Q Yuan; H Yang
Journal:  Brain Res       Date:  2000-06-16       Impact factor: 3.252

10.  Intracisternal urocortin inhibits vagally stimulated gastric motility in rats: role of CRF(2).

Authors:  C-Y Chen; M Million; D W Adelson; V Martínez; J Rivier; Y Taché
Journal:  Br J Pharmacol       Date:  2002-05       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.