OBJECTIVES: Gastric clearance of radiopaque markers (ROMs) has been proposed as an easy and noninvasive technique for assessment of gastric emptying. This study was conducted to evaluate the role of antral obliterating contractions in gastric emptying of ROMs in healthy volunteers. METHODS: Fifteen healthy volunteers, 12 males and three females, aged 21-38 yr, were enrolled in this study. Simultaneous recording of scintigraphic solid phase gastric emptying, gastric clearance of ROMs, and gastric manometry were performed after an overnight fast. The data of scintigraphic solid phase gastric emptying were expressed by half-emptying time (t1/2). The ROMs remaining in the stomach were counted fluoroscopically 2.5 and 4.5 h after the test meal. The time for the appearance of antral obliterating contractions after the meal was calculated. RESULTS: Six subjects (40%) passed all 10 ROMs after 4.5 h of recording. Among these six subjects, five had antral obliterating contractions 190-251 min (mean 232.2 +/- 24.3 min) after the test meal. There was no significant difference in t1/2 between subjects with or without antral obliterating contractions within the 4.5 h of recording. CONCLUSIONS: There was a considerable intersubject variation in the time of first antral obliterating contraction after the test meal. In the healthy volunteers, all ROMs were passed when there was a postprandial antral obliterating contraction. However, some of the ROMs still passed from the stomach in the absence of antral obliterating contractions.
OBJECTIVES: Gastric clearance of radiopaque markers (ROMs) has been proposed as an easy and noninvasive technique for assessment of gastric emptying. This study was conducted to evaluate the role of antral obliterating contractions in gastric emptying of ROMs in healthy volunteers. METHODS: Fifteen healthy volunteers, 12 males and three females, aged 21-38 yr, were enrolled in this study. Simultaneous recording of scintigraphic solid phase gastric emptying, gastric clearance of ROMs, and gastric manometry were performed after an overnight fast. The data of scintigraphic solid phase gastric emptying were expressed by half-emptying time (t1/2). The ROMs remaining in the stomach were counted fluoroscopically 2.5 and 4.5 h after the test meal. The time for the appearance of antral obliterating contractions after the meal was calculated. RESULTS: Six subjects (40%) passed all 10 ROMs after 4.5 h of recording. Among these six subjects, five had antral obliterating contractions 190-251 min (mean 232.2 +/- 24.3 min) after the test meal. There was no significant difference in t1/2 between subjects with or without antral obliterating contractions within the 4.5 h of recording. CONCLUSIONS: There was a considerable intersubject variation in the time of first antral obliterating contraction after the test meal. In the healthy volunteers, all ROMs were passed when there was a postprandial antral obliterating contraction. However, some of the ROMs still passed from the stomach in the absence of antral obliterating contractions.
Authors: Michael Camilleri; Braden Kuo; Linda Nguyen; Vida M Vaughn; Jessica Petrey; Katarina Greer; Rena Yadlapati; Thomas L Abell Journal: Am J Gastroenterol Date: 2022-06-03 Impact factor: 12.045