| Literature DB >> 9149110 |
D M Segal1, C T Moraes, D C Mash.
Abstract
The effects of chronic cocaine use on D3 receptor mRNA expression in the human nucleus accumbens was assessed by reverse transcription-polymerase chain reaction. D3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased 6-fold in cocaine overdose victims as compared to age-matched and drug-free control subjects. This finding demonstrates that chronic cocaine exposure leads to adaptive increases in the expression of D3 receptor mRNA in a critical reward center in brain.Entities:
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Year: 1997 PMID： 9149110 DOI： 10.1016/s0169-328x(97)00025-9
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X