Literature DB >> 9146556

Methotrexate-induced toxic epidermal necrolysis in a patient with psoriasis.

E J Primka1, C Camisa.   

Abstract

We describe a fatal case of low-dose methotrexate (MTX) toxicity in a patient with psoriasis, emphasizing the factors that exacerbate MTX toxicity and presenting rescue techniques. The patient had a toxic epidermal necrolysis-like condition. MTX cutaneous reactions ranging from toxic epidermal necrolysis to specific ulcerations have been described. The use of granulocyte colony stimulating factor for leukopenia associated with MTX toxicity is discussed.

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Year:  1997        PMID： 9146556     DOI： 10.1016/s0190-9622(97)70029-x

Source DB:  PubMed          Journal:  J Am Acad Dermatol        ISSN： 0190-9622            Impact factor:   11.527


  7 in total

1.  Acute mucocutaneous methotrexate toxicity with marked tissue eosinophilia.

Authors:  Luis J Borda; Andrew Ross; Gabriel Villada; Clara Milikowski
Journal:  BMJ Case Rep       Date:  2018-04-07

Review 2.  Drug-Induced Neutropenia During Treatment of Non-Neoplastic Dermatologic Diseases: A Review.

Authors:  Chang-Yu Hsieh; Tsen-Fang Tsai
Journal:  Clin Drug Investig       Date:  2020-10       Impact factor: 2.859

3.  Methotrexate-induced toxic epidermal necrolysis in a child.

Authors:  Ajay Gogia; Subha Pathania; Prasenjit Das; Yogendra K Gupta; Sameer Bakhshi
Journal:  Indian J Dermatol       Date:  2013-03       Impact factor: 1.494

4.  Methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides.

Authors:  Debra L Breneman; Timothy J Storer; John C Breneman; Diya F Mutasim
Journal:  Ther Clin Risk Manag       Date:  2008-10       Impact factor: 2.423

5.  Life-Threatening Gastrointestinal Mucosal Necrosis during Methotrexate Treatment for Rheumatoid Arthritis.

Authors:  Tomoya Tsukada; Tatsuo Nakano; Takashi Miyata; Shozo Sasaki
Journal:  Case Rep Gastroenterol       Date:  2013-11-06

6.  Toxic Epidermal Necrolysis Like Reaction due to Low-dose Methotrexate in a Case of Cutaneous Lupus Erythematosus: A Rare Occurrence.

Authors:  Karan Sancheti; Indrashis Podder; Ramesh Chandra Gharami
Journal:  Indian J Dermatol       Date:  2016 Jan-Feb       Impact factor: 1.494

7.  Methotrexate toxicity during treatment of chronic plaque psoriasis: a case report and review of the literature.

Authors:  Anja Weidmann; Amy C Foulkes; N Kirkham; N J Reynolds
Journal:  Dermatol Ther (Heidelb)       Date:  2014-06-19
  7 in total

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