Literature DB >> 9146041

Polymorphic changes of mannitol during freeze-drying: effect of surface-active agents.

R Haikala1, R Eerola, V P Tanninen, J Yliruusi.   

Abstract

The effect of polysorbate 80 on the crystalline properties of mannitol during freeze-drying was studied. Crystallinity and polymorphism play an important role in, e.g., the solubility and stability of freeze-dried products. Polysorbate 80 had an effect on both the polymorphism and the crystallinity of freeze-dried mannitol.

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Year:  1997        PMID： 9146041

Source DB:  PubMed          Journal:  PDA J Pharm Sci Technol        ISSN： 1079-7440


  4 in total

1.  Influence of ethanol on physical state of freeze-dried mannitol.

Authors:  Akira Takada; Steven L Nail; Masakatsu Yonese
Journal:  Pharm Res       Date:  2009-01-28       Impact factor: 4.200

2.  Influence of processing conditions on the physical state of mannitol--implications in freeze-drying.

Authors:  Xiangmin Liao; Rajesh Krishnamurthy; Raj Suryanarayanan
Journal:  Pharm Res       Date:  2007-02       Impact factor: 4.200

3.  Influence of crystallizing and non-crystallizing cosolutes on trehalose crystallization during freeze-drying.

Authors:  Prakash Sundaramurthi; Raj Suryanarayanan
Journal:  Pharm Res       Date:  2010-09-08       Impact factor: 4.200

4.  Effective inhibition of mannitol crystallization in frozen solutions by sodium chloride.

Authors:  Chitra Telang; Lian Yu; Raj Suryanarayanan
Journal:  Pharm Res       Date:  2003-04       Impact factor: 4.200
  4 in total

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