R Thiel1, J D Pearson, J I Epstein, P C Walsh, H B Carter. 1. Department of Urology, Johns Hopkins University School of Medicine, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-2101, USA.
Abstract
OBJECTIVES: Prostate-specific antigen (PSA) velocity prior to radical retropubic prostatectomy was evaluated to determine if men with a faster rate of rise in PSA have locally more extensive prostate cancer. METHODS: Of 368 men who underwent radical retropubic prostatectomy, 82 had two to seven PSA measurements between 1.3 and 6.7 years before prostate biopsy for evaluation of PSA velocity. PSA velocity and the pretreatment parameters of PSA, Gleason score, and T stage were evaluated as predictive parameters of pathologic stage. RESULTS: In men with pathologically organ-confined disease, PSA velocity was 1.12 ng/mL/yr; in non-organ-confined cases, it was 1.88 ng/mL/yr. There was a statistically significant relationship between a Gleason score of 7 and above and the pathologic extent of disease. There was no statistically significant relationship between T stage, the PSA at diagnosis, and PSA velocity with respect to final pathologic stage. CONCLUSIONS: PSA velocity is not a strong predictor of pathologic stage in men with localized prostate cancer.
OBJECTIVES:Prostate-specific antigen (PSA) velocity prior to radical retropubic prostatectomy was evaluated to determine if men with a faster rate of rise in PSA have locally more extensive prostate cancer. METHODS: Of 368 men who underwent radical retropubic prostatectomy, 82 had two to seven PSA measurements between 1.3 and 6.7 years before prostate biopsy for evaluation of PSA velocity. PSA velocity and the pretreatment parameters of PSA, Gleason score, and T stage were evaluated as predictive parameters of pathologic stage. RESULTS: In men with pathologically organ-confined disease, PSA velocity was 1.12 ng/mL/yr; in non-organ-confined cases, it was 1.88 ng/mL/yr. There was a statistically significant relationship between a Gleason score of 7 and above and the pathologic extent of disease. There was no statistically significant relationship between T stage, the PSA at diagnosis, and PSA velocity with respect to final pathologic stage. CONCLUSIONS: PSA velocity is not a strong predictor of pathologic stage in men with localized prostate cancer.
Authors: M Frank O'Brien; Angel M Cronin; Paul A Fearn; Caroline J Savage; Brandon Smith; Jason Stasi; Peter T Scardino; Gabrielle Fisher; Jack Cuzick; Henrik Møller; R Timothy Oliver; Daniel M Berney; Christopher S Foster; James A Eastham; Andrew J Vickers; Hans Lilja Journal: Int J Cancer Date: 2011-05-15 Impact factor: 7.396
Authors: Vadim Y Dudkin; Justin S Miller; Anna S Dudkina; Christophe Antczak; David A Scheinberg; Samuel J Danishefsky Journal: J Am Chem Soc Date: 2008-09-18 Impact factor: 15.419
Authors: Matthew Frank O'Brien; Angel M Cronin; Paul A Fearn; Brandon Smith; Jason Stasi; Bertrand Guillonneau; Peter T Scardino; James A Eastham; Andrew J Vickers; Hans Lilja Journal: J Clin Oncol Date: 2009-06-08 Impact factor: 44.544