Literature DB >> 9145902

Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae.

E Memili1, B Weisblum.   

Abstract

We compared ermSF induction in wild-type Streptomyces fradiae NRRL B-2702 and that in GS-14, a tylA mutant which cannot synthesize tylosin. Our findings suggest that (i) endogenously synthesized tylosin plays an obligatory role in ermSF induction and (ii) tylosin, or a biosynthetic intermediate beyond tylactone, has an "autocrine" function that induces ErmSF synthesis, thereby enabling S. fradiae to resist higher levels of tylosin.

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Year:  1997        PMID： 9145902      PMCID： PMC163883     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

Review 1.  Paper chromatography of antibiotics.

Authors:  V Betina
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  Transcriptional attenuation control of the tylosin-resistance gene tlrA in Streptomyces fradiae.

Authors:  G H Kelemen; M Zalacain; E Culebras; E T Seno; E Cundliffe
Journal:  Mol Microbiol       Date:  1994-11       Impact factor: 3.501

Review 3.  Insights into erythromycin action from studies of its activity as inducer of resistance.

Authors:  B Weisblum
Journal:  Antimicrob Agents Chemother       Date:  1995-04       Impact factor: 5.191

4.  Cloning and expression of a tylosin resistance gene from a tylosin-producing strain of Streptomyces fradiae.

Authors:  V A Birmingham; K L Cox; J L Larson; S E Fishman; C L Hershberger; E T Seno
Journal:  Mol Gen Genet       Date:  1986-09

5.  Sequence similarity between macrolide-resistance determinants and ATP-binding transport proteins.

Authors:  B Schoner; M Geistlich; P Rosteck; R N Rao; E Seno; P Reynolds; K Cox; S Burgett; C Hershberger
Journal:  Gene       Date:  1992-06-15       Impact factor: 3.688

6.  23S rRNA domain V, a fragment that can be specifically methylated in vitro by the ErmSF (TlrA) methyltransferase.

Authors:  D Kovalic; R B Giannattasio; H J Jin; B Weisblum
Journal:  J Bacteriol       Date:  1994-11       Impact factor: 3.490

7.  The macrolide-lincosamide-streptogramin B resistance phenotypes characterized by using a specifically deleted, antibiotic-sensitive strain of Streptomyces lividans.

Authors:  J L Pernodet; S Fish; M H Blondelet-Rouault; E Cundliffe
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

8.  Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin.

Authors:  R H Baltz; E T Seno
Journal:  Antimicrob Agents Chemother       Date:  1981-08       Impact factor: 5.191

9.  Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport.

Authors:  P R Rosteck; P A Reynolds; C L Hershberger
Journal:  Gene       Date:  1991-06-15       Impact factor: 3.688

10.  Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae.

Authors:  S Kamimiya; B Weisblum
Journal:  J Bacteriol       Date:  1988-04       Impact factor: 3.490
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  2 in total

1.  Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides.

Authors:  Mashal M Almutairi; Sung Ryeol Park; Simon Rose; Douglas A Hansen; Nora Vázquez-Laslop; Stephen Douthwaite; David H Sherman; Alexander S Mankin
Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-05       Impact factor: 11.205

2.  Transcriptional Regulation of Congocidine (Netropsin) Biosynthesis and Resistance.

Authors:  Audrey Vingadassalon; Florence Lorieux; Maud Juguet; Alba Noël; Luisa D F Santos; Laura Marin Fernandez; Jean-Luc Pernodet; Stéphanie Bury-Moné; Sylvie Lautru
Journal:  Appl Environ Microbiol       Date:  2021-09-29       Impact factor: 5.005
  2 in total

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