Literature DB >> 9145787

The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia.

I Sora1, M Funada, G R Uhl.   

Abstract

Interactions between delta-opioid receptors and morphine-preferring mu-opioid receptor subtypes have been suggested. Availability of transgenic mu-opioid receptor knockout mice allows assessment of mu-opioid receptor roles in the analgesia produced by the classical delta-opioid receptor agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) in hot-plate and tail-flick tests. DPDPE analgesia was dramatically reduced in mu-opioid receptor knockout mice in a gene-dose-dependent fashion. The analgesia induced by this classic delta-opioid receptor agonist depends on intact mu-opioid receptors, suggesting that selective delta-opioid receptor drugs may require mu-opioid receptor occupancies for full efficacy.

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Year:  1997        PMID： 9145787     DOI： 10.1016/s0014-2999(97)10016-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  31 in total

1.  Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.

Authors:  I Gomes; B A Jordan; A Gupta; N Trapaidze; V Nagy; L A Devi
Journal:  J Neurosci       Date:  2000-11-15       Impact factor: 6.167

2.  Sex differences in the effects of adolescent social deprivation on alcohol consumption in μ-opioid receptor knockout mice.

Authors:  Yuki Moriya; Yoshiyuki Kasahara; F Scott Hall; Yasufumi Sakakibara; George R Uhl; Hiroaki Tomita; Ichiro Sora
Journal:  Psychopharmacology (Berl)       Date:  2014-11-04       Impact factor: 4.530

3.  A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.

Authors:  Severo Salvadori; Claudio Trapella; Stella Fiorini; Lucia Negri; Roberta Lattanzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Gianfranco Balboni
Journal:  Bioorg Med Chem       Date:  2007-08-29       Impact factor: 3.641

4.  Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats.

Authors:  C Courteix; M A Coudoré-Civiale; A M Privat; J M Zajac; A Eschalier; J Fialip
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

Review 5.  Placentophagy: therapeutic miracle or myth?

Authors:  Cynthia W Coyle; Kathryn E Hulse; Katherine L Wisner; Kara E Driscoll; Crystal T Clark
Journal:  Arch Womens Ment Health       Date:  2015-06-04       Impact factor: 3.633

6.  A gene-based method for detecting gene-gene co-association in a case-control association study.

Authors:  Qianqian Peng; Jinghua Zhao; Fuzhong Xue
Journal:  Eur J Hum Genet       Date:  2009-12-23       Impact factor: 4.246

7.  Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse.

Authors:  Y Zhu; M S Hsu; J E Pintar
Journal:  J Neurosci       Date:  1998-04-01       Impact factor: 6.167

8.  Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.

Authors:  L Gendron; J E Pintar; C Chavkin
Journal:  Neuroscience       Date:  2007-10-05       Impact factor: 3.590

Review 9.  The effects of opioids and opioid analogs on animal and human endocrine systems.

Authors:  Cassidy Vuong; Stan H M Van Uum; Laura E O'Dell; Kabirullah Lutfy; Theodore C Friedman
Journal:  Endocr Rev       Date:  2009-11-10       Impact factor: 19.871

10.  Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS.

Authors:  Gina F Marrone; Steven G Grinnell; Zhigang Lu; Grace C Rossi; Valerie Le Rouzic; Jin Xu; Susruta Majumdar; Ying-Xian Pan; Gavril W Pasternak
Journal:  Proc Natl Acad Sci U S A       Date:  2016-03-14       Impact factor: 11.205
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