| Literature DB >> 9145503 |
S Rahman1, N Fukamiya, N Ohno, H Tokuda, H Nishino, K Tagahara, K H Lee, M Okano.
Abstract
Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for semisynthetic quassinoids (3-7), which were obtained by esterification of the C-15 OH group of deacetylated isobrucein-B (2). All the ester derivatives showed higher antitumor promoting activity than that of the potent compound 2. A compound containing a fluorinated aliphatic ester showed the highest potency.Entities:
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Year: 1997 PMID： 9145503 DOI： 10.1248/cpb.45.675
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645