| Literature DB >> 9145101 |
S Rüdiger1, A Buchberger, B Bukau.
Abstract
Determination of the structure of the substrate binding domain of the Escherichia coli Hsp70 chaperone, DnaK, and the biochemical characterisation of the motif it recognizes within substrates provide insights into the principles governing Hsp70 interaction with polypeptide chains. DnaK recognizes extended peptide strands composed of up to five consecutive hydrophobic residues within and positively charged residues outside the substrate binding cavity.Entities:
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Year: 1997 PMID： 9145101 DOI： 10.1038/nsb0597-342
Source DB: PubMed Journal: Nat Struct Biol ISSN： 1072-8368