Literature DB >> 9144665

(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.

A J Doherty1, M J Palmer, J M Henley, G L Collingridge, D E Jane.   

Abstract

A new phenylglycine derivative, (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), has been synthesized and shown to selectively activate mGlu5a receptors, compared to mGlu1 alpha receptors, when expressed in CHO cells. This selective mGlu5 receptor agonist also potentiates NMDA-induced depolarizations in rat hippocampal slices. CHPG may be a useful tool for studying the role of mGlu5 receptors in the central nervous system.

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Year:  1997        PMID： 9144665     DOI： 10.1016/s0028-3908(97)00001-4

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  77 in total

1.  A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices.

Authors:  A J Doherty; M J Palmer; Z A Bortolotto; A Hargreaves; A E Kingston; P L Ornstein; D D Schoepp; D Lodge; G L Collingridge
Journal:  Br J Pharmacol       Date:  2000-09       Impact factor: 8.739

2.  Effect of the umami peptides on the ligand binding and function of rat mGlu4a receptor might implicate this receptor in the monosodium glutamate taste transduction.

Authors:  K Monastyrskaia; K Lundstrom; D Plahl; G Acuna; C Schweitzer; P Malherbe; V Mutel
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

3.  Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.

Authors:  D M O'Leary; V Movsesyan; S Vicini; A I Faden
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

4.  Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade.

Authors:  Mark R Stefani; Bita Moghaddam
Journal:  Eur J Pharmacol       Date:  2010-04-02       Impact factor: 4.432

Review 5.  Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.

Authors:  M Foster Olive
Journal:  Eur J Pharmacol       Date:  2010-04-02       Impact factor: 4.432

Review 6.  Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias.

Authors:  K Sengmany; K J Gregory
Journal:  Br J Pharmacol       Date:  2015-11-11       Impact factor: 8.739

7.  Functional interaction between mGlu 5 and NMDA receptors in a rat model of Parkinson's disease.

Authors:  Nathalie Turle-Lorenzo; Nathalie Breysse; Christelle Baunez; Marianne Amalric
Journal:  Psychopharmacology (Berl)       Date:  2005-02-22       Impact factor: 4.530

Review 8.  Ionotropic and metabotropic glutamate receptor structure and pharmacology.

Authors:  James N C Kew; John A Kemp
Journal:  Psychopharmacology (Berl)       Date:  2005-02-25       Impact factor: 4.530

9.  Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei.

Authors:  Silvarosa Grassi; Adele Frondaroli; Vito Enrico Pettorossi
Journal:  J Physiol       Date:  2002-09-15       Impact factor: 5.182

10.  G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration.

Authors:  Vincent Degos; Stéphane Peineau; Cora Nijboer; Angela M Kaindl; Stéphanie Sigaut; Géraldine Favrais; Frank Plaisant; Natacha Teissier; Elodie Gouadon; Alain Lombet; Elie Saliba; Graham L Collingridge; Mervyn Maze; Ferdinando Nicoletti; Cobi Heijnen; Jean Mantz; Annemieke Kavelaars; Pierre Gressens
Journal:  Ann Neurol       Date:  2013-03-14       Impact factor: 10.422
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