Literature DB >> 9144532

Differential expression of PPAR gamma1 and gamma2 isoforms in human adipose tissue.

T Yanase1, T Yashiro, K Takitani, S Kato, S Taniguchi, R Takayanagi, H Nawata.   

Abstract

One of the essential factors for adipogenesis, peroxisome proliferator activated receptor gamma (PPAR gamma), is classified into two isoforms, gamma1 and gamma2 encoded by a single PPAR gamma gene. To examine the mode of expressions of both the PPAR gamma1 and gamma2 isoforms in human adipose tissue, we cloned a partial cDNA of the human PPAR gamma2 (hPPAR gamma2) from a human adipose tissue cDNA library. The sequence encoded an additional 28 amino acids amino-terminal to the first ATG codon of hPPAR gamma1. The simultaneous quantitation of hPPAR gamma1 and gamma2 mRNA in subcutaneous or visceral (mesenteric) fat tissue from 10 different individuals was performed by an RNase protection assay and revealed a relatively higher expression of gamma1 than gamma2 in all specimens examined.

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Year:  1997        PMID： 9144532     DOI： 10.1006/bbrc.1997.6446

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells.

Authors:  Sarah G Harris; Richard P Phipps
Journal:  Immunology       Date:  2002-01       Impact factor: 7.397

2.  Adipose tissue distribution and quantification of PPARbeta/delta and PPARgamma1-3 mRNAs: discordant gene expression in subcutaneous, retroperitoneal and visceral adipose tissue of morbidly obese patients.

Authors:  Josiane Woutheres Bortolotto; Rogério Margis; Angela Cristine Bersch Ferreira; Alexandre Vontobel Padoin; Cláudio Cora Mottin; Regina Maria Guaragna
Journal:  Obes Surg       Date:  2007-07       Impact factor: 4.129

3.  Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles.

Authors:  Denise M Ray; Sherry L Spinelli; Stephen J Pollock; Thomas I Murant; Jamie J O'Brien; Neil Blumberg; Charles W Francis; Mark B Taubman; Richard P Phipps
Journal:  Thromb Haemost       Date:  2008-01       Impact factor: 5.249

4.  The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation.

Authors:  Kari M Wojtanik; Keith Edgemon; Srikant Viswanadha; Brigette Lindsey; Martin Haluzik; Weiping Chen; George Poy; Marc Reitman; Constantine Londos
Journal:  J Lipid Res       Date:  2009-02-05       Impact factor: 5.922

5.  Evaluation of peroxisome proliferator-activated receptor agonists on interleukin-5-induced eosinophil differentiation.

Authors:  Steven G Smith; Mike Hill; John-Paul Oliveria; Brittany M Watson; Adrian J Baatjes; Benny Dua; Karen Howie; Heather Campbell; Rick M Watson; Roma Sehmi; Gail M Gauvreau
Journal:  Immunology       Date:  2014-07       Impact factor: 7.397

6.  Regulation of uncoupling protein-2 mRNA in L6 myotubules: I: Thiazolidinediones stimulate uncoupling protein-2 gene expression by a mechanism requiring ongoing protein synthesis and an active mitogen-activated protein kinase.

Authors:  Irma López-Solache; Véronique Marie; Erika Vignault; Anne Camirand; J Enrique Silva
Journal:  Endocrine       Date:  2002-11       Impact factor: 3.925

7.  Identification of Posttranslational Modifications in Peroxisome Proliferator-Activated Receptor γ Using Mass Spectrometry.

Authors:  Shogo Katsura; Tomoko Okumura; Ryo Ito; Akira Sugawara; Atsushi Yokoyama
Journal:  PPAR Res       Date:  2014-06-25       Impact factor: 4.964

8.  Genotype-based recall to study metabolic effects of genetic variation: a pilot study of PPARG Pro12Ala carriers.

Authors:  Prasad G Kamble; Stefan Gustafsson; Maria J Pereira; Per Lundkvist; Naomi Cook; Lars Lind; Paul W Franks; Tove Fall; Jan W Eriksson; Erik Ingelsson
Journal:  Ups J Med Sci       Date:  2018-01-05       Impact factor: 2.384

9.  Association of DNA Methylation Levels with Tissue-specific Expression of Adipogenic and Lipogenic Genes in Longissimus dorsi Muscle of Korean Cattle.

Authors:  M Baik; T T T Vu; M Y Piao; H J Kang
Journal:  Asian-Australas J Anim Sci       Date:  2014-10       Impact factor: 2.509
  9 in total

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