BACKGROUND: Several epidemiologic investigations have established a link between Helicobacter pylori infection and gastric malignancies. Because the stomach is in continuity with the oral cavity and the bacterium has been isolated from dental plaque and saliva, we hypothesized that H. pylori infection of the upper aerodigestive tract might result in mucosal disruption, allowing for subsequent transformation by known carcinogens such as tobacco and alcohol. METHODS: To test this hypothesis, we assayed for the presence of IgG antibodies to H. pylori in the serum of 21 patients with squamous cell carcinoma of the head and neck (SCCHN) and 21 matched controls without a history of head and neck cancer. RESULTS: The incidence of seropositivity in the SCCHN patients was 57% and in the controls, 62% (p > 0.05). CONCLUSIONS: These data do not support an etiologic role for H. pylori infection in head and neck cancer.
BACKGROUND: Several epidemiologic investigations have established a link between Helicobacter pylori infection and gastric malignancies. Because the stomach is in continuity with the oral cavity and the bacterium has been isolated from dental plaque and saliva, we hypothesized that H. pyloriinfection of the upper aerodigestive tract might result in mucosal disruption, allowing for subsequent transformation by known carcinogens such as tobacco and alcohol. METHODS: To test this hypothesis, we assayed for the presence of IgG antibodies to H. pylori in the serum of 21 patients with squamous cell carcinoma of the head and neck (SCCHN) and 21 matched controls without a history of head and neck cancer. RESULTS: The incidence of seropositivity in the SCCHN patients was 57% and in the controls, 62% (p > 0.05). CONCLUSIONS: These data do not support an etiologic role for H. pyloriinfection in head and neck cancer.
Authors: Ismail Yilmaz; E Erkul; U Berber; Z Kucukodaci; G Narli; A Haholu; D Demirel Journal: Eur Arch Otorhinolaryngol Date: 2015-02-27 Impact factor: 2.503
Authors: Isabel Adler; Andrea Muiño; Silvia Aguas; Laura Harada; Mariana Diaz; Adriana Lence; Mario Labbrozzi; Juan Manuel Muiño; Boris Elsner; Alejandra Avagnina; Valeria Denninghoff Journal: World J Gastroenterol Date: 2014-08-07 Impact factor: 5.742
Authors: Eugenia H Miranti; Neal D Freedman; Stephanie J Weinstein; Christian C Abnet; Jacob Selhub; Gwen Murphy; Lena Diaw; Satu Männistö; Philip R Taylor; Demetrius Albanes; Rachael Z Stolzenberg-Solomon Journal: Am J Clin Nutr Date: 2016-08-17 Impact factor: 7.045
Authors: Laith Khasawneh; Adi H Khassawneh; Khalid A Kheirallah; Giampiero Neri; Giulio Filograna Pignatelli; Hasan Ibrahim Al-Balas; Stefano Martinotti; Abdel-Hameed Al-Mistarehi Journal: Ann Med Surg (Lond) Date: 2021-01-24