Literature DB >> 9141650

Immunocytochemical detection of the neurokinin B receptor (NK3) on melanin-concentrating hormone (MCH) neurons in rat brain.

B Griffond1, P Ciofi, L Bayer, C Jacquemard, D Fellmann.   

Abstract

The presence of the neurokinin B receptor (NK3 receptor) in the rat lateral hypothalamus and the zona incerta was previously reported. The aim of the present study was to define its cellular localization in these areas. Investigations, coupling immunocytochemical and in situ hybridization techniques, focussed on two neuron populations: the melanin-concentrating hormone (MCH) neurons and a population of neurons recognized by an ovine prolactin antiserum (PRL-ir neurons). While PRL-ir neurons did not exhibit NK3 immunoreactivity, 57% +/- 6% of MCH neurons were strongly stained by the NK3 antiserum. These results suggest that neurokinin B is involved in the regulation of MCH neuron activity via the NK3 receptor; they provide new bases for further investigations on MCH role in the control of food and water intake.

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Year:  1997        PMID： 9141650     DOI： 10.1016/s0891-0618(96)00200-1

Source DB:  PubMed          Journal:  J Chem Neuroanat        ISSN： 0891-0618            Impact factor:   3.052


  7 in total

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7.  Neurokinin B-Expressing Neurons of the Central Extended Amygdala Mediate Inhibitory Synaptic Input onto Melanin-Concentrating Hormone Neuron Subpopulations.

Authors:  Akie Fujita; Lily Zhong; Monica S Antony; Elizabeth Chamiec-Case; Laura E Mickelsen; Scott E Kanoski; William F Flynn; Alexander C Jackson
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  7 in total

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