Literature DB >> 9140198

Bovine coronavirus I protein synthesis follows ribosomal scanning on the bicistronic N mRNA.

S D Senanayake1, D A Brian.   

Abstract

The mRNA encoding the 49-kDa nucleocapsid protein (N) of the bovine coronavirus is bicistronic. A 23-kDa protein, termed the I protein for the 'internal' open reading frame (ORF), is also synthetized but in the +1 reading frame beginning 61 nt downstream of the N start codon. Sequences flanking the N and I start codons suggest that the I ORF might be accessed by scanning ribosomes passing over the N start codon. Here we test this idea and demonstrate with translation studies both in vitro and in vivo that the I protein is synthesized according to the leaky scanning model for initiation of translation on the subgenomic N mRNA molecule.

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Year:  1997        PMID： 9140198      PMCID： PMC7134031          DOI： 10.1016/s0168-1702(96)01423-2

Source DB:  PubMed          Journal:  Virus Res        ISSN： 0168-1702            Impact factor:   3.303


  18 in total

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5.  Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.

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10.  Sequence analysis of the nucleoprotein genes of three enterotropic strains of murine coronavirus.

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  23 in total

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