BACKGROUND: Viral hepatitis E (HIV) frequently causes epidemic outbreaks in many developing countries. It is also present in developed countries as imported cases. The role of hepatitis A virus as trigger for autoimmune chronic hepatitis has been demonstrated, and it has been suggested that this may also apply to HEV. METHODS: The presence of anti-HEV antibodies in serum samples from patients with autoimmune chronic active hepatitis (n = 52) and with primary biliary cirrhosis (n = 25) was investigated using an Abbott assay and a peptide-based test. RESULTS: Anti-HEV antibodies were detected with the Abbott test in 13% (7 of 52) of the patients with autoimmune chronic active hepatitis, but not of these were positive in the synthetic peptide-based test. CONCLUSION: These findings indicate the HEV is not associated with primary biliary cirrhosis but may be implicated in some cases of autoimmune chronic active hepatitis.
BACKGROUND:Viral hepatitis E (HIV) frequently causes epidemic outbreaks in many developing countries. It is also present in developed countries as imported cases. The role of hepatitis A virus as trigger for autoimmune chronic hepatitis has been demonstrated, and it has been suggested that this may also apply to HEV. METHODS: The presence of anti-HEV antibodies in serum samples from patients with autoimmune chronic active hepatitis (n = 52) and with primary biliary cirrhosis (n = 25) was investigated using an Abbott assay and a peptide-based test. RESULTS: Anti-HEV antibodies were detected with the Abbott test in 13% (7 of 52) of the patients with autoimmune chronic active hepatitis, but not of these were positive in the synthetic peptide-based test. CONCLUSION: These findings indicate the HEV is not associated with primary biliary cirrhosis but may be implicated in some cases of autoimmune chronic active hepatitis.
Authors: Sven Pischke; Anett Gisa; Pothakamuri Venkata Suneetha; Steffen Björn Wiegand; Richard Taubert; Jerome Schlue; Karsten Wursthorn; Heike Bantel; Regina Raupach; Birgit Bremer; Behrend Johann Zacher; Reinhold Ernst Schmidt; Michael Peter Manns; Kinan Rifai; Torsten Witte; Heiner Wedemeyer Journal: PLoS One Date: 2014-01-21 Impact factor: 3.240
Authors: Richard Taubert; Jana Diestelhorst; Norman Junge; Martha M Kirstein; Sven Pischke; Arndt Vogel; Heike Bantel; Ulrich Baumann; Michael P Manns; Heiner Wedemeyer; Elmar Jaeckel Journal: Sci Rep Date: 2018-11-28 Impact factor: 4.379
Authors: Elisabeth Sucher; Robert Sucher; Tanja Gradistanac; Gerald Brandacher; Stefan Schneeberger; Thomas Berg Journal: J Immunol Res Date: 2019-11-25 Impact factor: 4.818