Literature DB >> 9140060

Vertebrate non-receptor protein-tyrosine kinase families.

K Neet1, T Hunter.   

Abstract

Many non-receptor protein-tyrosine kinases (PTKs) function as subunits of receptors, either receptors with or without intrinsic PTK catalytic activity of their own. There are currently at least 33 known vertebrate genes that encode non-receptor PTKs. These can be divided into nine families: Abl, Fes/Fer, Syk/Zap70, Jak, Tec, Fak, Ack, Src, and Csk. Four additional non-receptor PTKs (Rlk/Txk, Srm, Rak/Frk, and Brk/Sik) do not appear to belong to any of the defined families. Here we review current knowledge of the general roles of non-receptor PTKs, as well as the characteristic features and functions of each family and its family members.

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Year:  1996        PMID： 9140060     DOI： 10.1046/j.1365-2443.1996.d01-234.x

Source DB:  PubMed          Journal:  Genes Cells        ISSN： 1356-9597            Impact factor:   1.891


  41 in total

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Journal:  Neuropharmacology       Date:  2015-08-13       Impact factor: 5.250

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