Literature DB >> 9139698

Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion.

M Yamamoto1, A Bharti, Y Li, D Kufe.   

Abstract

The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in human breast carcinomas. The functional role of DF3 is unknown. The present studies demonstrate that DF3 associates with beta-catenin. Similar findings have been obtained for gamma-catenin but not alpha-catenin. DF3, like E-cadherin and the adenomatous polyposis coli gene product, contains an SXXXXXSSL site that is responsible for direct binding to beta-catenin. The results further demonstrate that interaction of DF3 and beta-catenin is dependent on cell adhesion. These findings and the role of beta-catenin in cell signaling support a role for DF3 in the adhesion of epithelial cells.

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Year:  1997        PMID： 9139698     DOI： 10.1074/jbc.272.19.12492

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  109 in total

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6.  MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells.

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7.  MUC1 mediates transendothelial migration in vitro by ligating endothelial cell ICAM-1.

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Journal:  Clin Exp Metastasis       Date:  2005       Impact factor: 5.150

8.  Detection of circulating anti-mucin 1 (MUC1) antibodies in breast tumor patients by indirect enzyme-linked immunosorbent assay using a recombinant MUC1 protein containing six tandem repeats and expressed in Escherichia coli.

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9.  Ligand activation of the androgen receptor downregulates E-cadherin-mediated cell adhesion and promotes apoptosis of prostatic cancer cells.

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10.  Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth.

Authors:  Shuhei Tanida; Kaoru Akita; Akiko Ishida; Yugo Mori; Munetoyo Toda; Mizue Inoue; Mariko Ohta; Masakazu Yashiro; Tetsuji Sawada; Kosei Hirakawa; Hiroshi Nakada
Journal:  J Biol Chem       Date:  2013-09-17       Impact factor: 5.157
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