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Literature DB >> 913923

Lipids in the pulmonary artery and the lungs of severely diabetic rats. A histochemical and chemical study.

Abstract

To investigate the effect of diabetes on the lipid composition of the lungs and of the pulmonary artery, 43 streptozotocin diabetic rats and 43 control rats were examined. Triglyceride deposits were observed by a histochemical method in the branches of the pulmonary artery in 10 diabetic rats but in none of the controls. In the pulmonary tissue of the diabetic rats the total lipid content was not different from that of control animals, but the relative amount of phospholipids was decreased (p less than 0.001), and that of non-esterified fatty acids (p less than 0.001) and triglycerides (p less than 0.05) increased as compared to the control rats. These results indicate abnormalities in the lipid metabolism of the pulmonary artery and lungs during insulin deficiency.

Entities: Chemical Disease Species

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Year: 1977 PMID： 913923 DOI： 10.1007/bf01223270

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

27 in total

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8 in total

1. Diabetes and the pulmonary circulation.

Authors: Brian Fouty
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2008-09-12 Impact factor: 5.464

2. Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity.

Authors: Laurent Plantier; Valérie Besnard; Yan Xu; Machiko Ikegami; Susan E Wert; Alan N Hunt; Anthony D Postle; Jeffrey A Whitsett
Journal: J Biol Chem Date: 2012-01-20 Impact factor: 5.157

3. Nodular fibrosis of the lung in diabetes mellitus.

Authors: J Fariña; V Furió; M J Fernandez-Aceñero; M A Muzas
Journal: Virchows Arch Date: 1995 Impact factor: 4.064

4. The influence of insulin on the lipids in the pulmonary artery and the lungs of severely diabetic rats. A histochemical and chemical study.

Authors: A Reinilä; H K Akerblom; V A Koivisto
Journal: Diabetologia Date: 1979-01 Impact factor: 10.122